{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:40:53Z","timestamp":1777927253053,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Hyperparathyroidism has been described in people living with HIV undergoing tenofovir disoproxil fumarate (TDF)-containing antiretroviral therapy (ART), but differences in calcium levels have never been investigated in detail. We aimed to compare the prevalence of hypocalcemia between patients with and without TDF-containing ART. The patients and methods were a retrospective cohort study in HIV-infected adult patients receiving dolutegravir and either abacavir (ABC)\/lamivudine (3TC) or TDF\/emtricitabine in a single center in Munich, Germany. Of 172 patients, 126 (73.3%) were male and the median age was 48.5 years (interquartile range 42\u201354). Average calcium levels were 2.24 (2.21\u20132.29)\u00a0mmol\/l and 2.21 (2.16\u20132.26)\u00a0mmol\/l (P\u2009&lt;\u20090.001) with a prevalence of at least one episode of total calcium &lt;2.12\u00a0mmol\/l of 16.2 and 34.4% in the groups treated with ABC\/3TC and TDF\/emtricitabine, respectively (P\u2009=\u20090.006). TDF use was independently associated with the occurrence of albumin-corrected calcium levels of &lt;2.12\u00a0mmol\/l (odds ratio: 6.7 [1.3\u201335.6]; P\u2009=\u20090.025). Hypocalcemia seems to occur more often in TDF-treated patients. Further research into hypocalcemia with TDF and potential cardiovascular effects may be of benefit based on these findings.<\/jats:p>","DOI":"10.1177\/0956462418815022","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T20:35:31Z","timestamp":1547152531000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Tenofovir disoproxil fumarate\/emtricitabine is associated with a higher risk of hypocalcemia compared to abacavir\/lamivudine \u2013 results from a German cohort study"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-3275","authenticated-orcid":false,"given":"S","family":"Noe","sequence":"first","affiliation":[{"name":"MVZ Karlsplatz, Research and Clinical Care Center, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Heldwein","sequence":"additional","affiliation":[{"name":"MVZ Karlsplatz, Research and Clinical Care Center, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Jaeger","sequence":"additional","affiliation":[{"name":"MVZ Karlsplatz, Research and Clinical Care Center, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Page","sequence":"additional","affiliation":[{"name":"Birmingham Heartlands HIV Service, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Wolf","sequence":"additional","affiliation":[{"name":"MUC Research, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"bibr1-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000248"},{"key":"bibr2-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000509"},{"key":"bibr3-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181caebaa"},{"key":"bibr4-0956462418815022","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.17.4.19568"},{"key":"bibr5-0956462418815022","doi-asserted-by":"publisher","DOI":"10.2174\/1574891X09666140609123138"},{"key":"bibr6-0956462418815022","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00563"},{"key":"bibr7-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181e12ed3"},{"key":"bibr8-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0693-4"},{"key":"bibr9-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2004.19.5.714"},{"key":"bibr10-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12641"},{"key":"bibr11-0956462418815022","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1502"},{"key":"bibr12-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833c3281"},{"key":"bibr13-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283454461"},{"key":"bibr14-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq158"},{"key":"bibr15-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0473-3-17"},{"key":"bibr16-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.037"},{"key":"bibr17-0956462418815022","doi-asserted-by":"crossref","unstructured":"Noe SC, Heldwein S, Wiese C, et\u00a0al. Secondary hyperparathyroidism in HIV infected patients.\n                      Central Europe Horm Metab Res\n                      2018; 50(4): 317\u2013324.","DOI":"10.1055\/s-0043-125073"},{"key":"bibr18-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328349060e"},{"key":"bibr19-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0052"},{"key":"bibr20-0956462418815022","doi-asserted-by":"crossref","unstructured":"Mace ML, Gravesen E, Nordholm A, et\u00a0al. Fibroblast growth factor (FGF) 23 regulates the plasma levels of parathyroid hormone in vivo through the FGF receptor in normocalcemia, but not in hypocalcemia.\n                      Calcif Tissue Int\n                      2018; 102(1): 85\u201392.","DOI":"10.1007\/s00223-017-0333-9"},{"key":"bibr21-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1627"},{"key":"bibr22-0956462418815022","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.039"},{"key":"bibr23-0956462418815022","author":"Chen R","journal-title":"J Am Heart Assoc"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462418815022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462418815022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462418815022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:39:00Z","timestamp":1777675140000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462418815022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1177\/0956462418815022"],"URL":"https:\/\/doi.org\/10.1177\/0956462418815022","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]}}}