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No study has systematically quantified the rate of newly acquired HPV infections from the published literature and determined its relationship with age. We performed a systematic review and meta-analysis to describe incident HPV infections in women. Medline\u00ae and Thomson Reuters Web of Science via PubMed\u00ae databases were searched. A total of 46 of 5136 studies met inclusion criteria and contributed results. We conducted a meta-regression analysis of 13 studies, which reported incidence rate estimates on over 13 high-risk HPV types, to provide pooled stratum-specific incidence rates and rate ratios for key population and study characteristics among 8488 women. Studies with mean age\u2009&lt;\u200930 years had relatively higher HPV incidence rates compared to studies with mean age \u226530 years: relative risk\u2009=\u20093.12; 95% CI: 1.41\u20136.93. HPV-16 was most frequently detected, followed by HPV-18: relative risk\u2009=\u20090.47; 95% CI: 0.33\u20130.67, and by HPV-58: relative risk =\u20090.45; 95% CI: 0.27\u20130.74. Younger age is a key predictor of genital HPV incidence in women. These data on the relative distribution of incident HPV infections will provide a baseline comparison for monitoring of changes in HPV incidence following the implementation of population-level HPV vaccination.<\/jats:p>","DOI":"10.1177\/0956462418824441","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T01:41:52Z","timestamp":1571794912000},"page":"1246-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Patterns of incident genital human papillomavirus infection in women: A literature review and meta-analysis"],"prefix":"10.1177","volume":"30","author":[{"given":"Bradford S","family":"Wheeler","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne 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