{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:03Z","timestamp":1777927263062,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Organ transplantation among people living with human immunodeficiency virus (PLHIV) is increasing. Guidelines recommend any changes in antiretroviral therapy (ART) prior to transplantation, but there are limited data regarding ART changes post transplantation. We report a case where an ART switch from a protease inhibitor-based regimen to dolutegravir plus emtricitabine\/tenofovir alafenamide in a renal transplant recipient led to subtherapeutic tacrolimus concentrations and an increased serum creatinine (SCr). A workup for graft rejection was performed (including kidney biopsy and cytomegalovirus and BK virus polymerase chain reaction) following the rise in SCr, which was higher than expected from dolutegravir initiation (via organ cation transporter 2 inhibition). This case highlights the potential challenges of switching ART regimens in PLHIV post transplantation.<\/jats:p>","DOI":"10.1177\/0956462419829989","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T21:27:51Z","timestamp":1554758871000},"page":"710-714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Drug interaction after ritonavir discontinuation: considerations for antiretroviral therapy changes in renal transplant recipients"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-1767","authenticated-orcid":false,"given":"Humberto R","family":"Jimenez","sequence":"first","affiliation":[{"name":"Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA"},{"name":"Pharmacy Department, Saint Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla M","family":"Natali","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Saint Joseph\u2019s University Medical Center, Paterson, NJ, USA"},{"name":"Pharmacy Department, Saint Michael\u2019s Medical Center, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Abdel Rahman","family":"Zahran","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Saint Joseph\u2019s University Medical Center, Paterson, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"bibr1-0956462419829989","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868070-00006"},{"key":"bibr2-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu919"},{"key":"bibr3-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl337"},{"key":"bibr4-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu617"},{"key":"bibr5-0956462419829989","unstructured":"Department of Health and Human Services. Organ Procurement and Transplantation Network website, https:\/\/optn.transplant.hrsa.gov\/learn\/professional-education\/hope-act\/ (accessed 28 April 2018)."},{"key":"bibr6-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2012.0169"},{"key":"bibr7-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02684.x"},{"key":"bibr8-0956462419829989","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.22.328"},{"key":"bibr9-0956462419829989","volume-title":"Norvir (package insert)","author":"AbbVie, Inc.","year":"2017"},{"key":"bibr10-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq054"},{"key":"bibr11-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.268"},{"key":"bibr12-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H423"},{"key":"bibr13-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001197"},{"key":"bibr14-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070726"},{"key":"bibr15-0956462419829989","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10414.1"},{"key":"bibr16-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14419"},{"key":"bibr17-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416651528"},{"key":"bibr18-0956462419829989","volume-title":"Tivicay (package insert)","author":"Viiv Healthcare","year":"2013"},{"key":"bibr19-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04440.x"},{"key":"bibr20-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70290-0"},{"key":"bibr21-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70257-3"},{"key":"bibr22-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215541"},{"key":"bibr23-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60084-2"},{"key":"bibr24-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61221-0"},{"key":"bibr25-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu051"},{"key":"bibr26-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12545"},{"key":"bibr27-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1985.tb06340.x"},{"key":"bibr28-0956462419829989","volume-title":"Bactrim (package insert)","author":"AR Scientific Inc","year":"2013"},{"key":"bibr29-0956462419829989","volume-title":"Lopid (package insert)","author":"Pfizer","year":"2008"},{"key":"bibr30-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60616-X"},{"key":"bibr31-0956462419829989","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000908"},{"key":"bibr32-0956462419829989","unstructured":"Wohl D, Thalme A, Finlayson R, et\u00a0al. 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