{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:10Z","timestamp":1777927270529,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>\n                    We report the case of a previously healthy 29-year-old man who has sex with men who was admitted with sub-acute onset of headache, seizures and altered mental status. Physical examination revealed oral thrush, mental confusion and right hemiparesis. An unenhanced computed tomography of the brain revealed multiple rounded hemorrhages associated with perilesional edema and no enhancement was seen after contrast infusion. A rapid test for HIV-1 was positive and the CD4 T-lymphocyte count was 120 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    . Pyrimethamine, sulfadiazine plus folinic acid and dexamethasome were started. After two weeks of treatment, the clinical condition and neuroimaging of the patient remained unaltered. A stereotactic brain biopsy was performed and the histopathologic examination confirmed the diagnosis of hemorrhagic toxoplasmosis. After a longer course of anti-Toxoplasma treatment due to an incomplete clinical and radiological response, the patient was discharged home. Hemorrhagic toxoplasmosis is a rare presentation of cerebral toxoplasmosis and should be considered in the differential diagnosis of hemorrhagic cerebral lesions in HIV-infected patients in order to initiate specific treatment promptly.\n                  <\/jats:p>","DOI":"10.1177\/0956462419845965","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T02:11:00Z","timestamp":1559614260000},"page":"930-933","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemorrhagic brain lesions in a newly diagnosed HIV-1 infected patient"],"prefix":"10.1177","volume":"30","author":[{"given":"D","family":"Pellegrino","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Instituto Medicina, Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Picciarelli","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculdade de Medicina, Hospital das Clinicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto C\u00e9sar Penalva","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto Medicina, Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-8716","authenticated-orcid":false,"given":"Jos\u00e9 E","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Instituto Medicina, Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"},{"name":"Department of Infectious Diseases, Faculdade de Medicina, Hospital das Clinicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"bibr1-0956462419845965","doi-asserted-by":"publisher","DOI":"10.1086\/424877"},{"key":"bibr2-0956462419845965","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00137-X"},{"key":"bibr3-0956462419845965","unstructured":"Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. 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