{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:17:26Z","timestamp":1782955046381,"version":"3.54.5"},"reference-count":42,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Shigella is a leading cause of gastroenteritis worldwide; however, data on clinical outcomes amongst adults are lacking. All adult cases (&gt;16\u2009years) of Shigella gastroenteritis diagnosed between January 2014 to December 2017 at an East London NHS Trust in the United Kingdom were included. Demographic, clinical, microbiological and whole genome sequencing (WGS) data were retrospectively collected. Shigella spp isolates from 169 cases were identified: S. flexneri 90 (53.3%), S. sonnei 75 (44.9%) and S. boydii 4 (2.0%). The median age was 34\u2009years (IQR 29\u201345), and 127 (75.1%) were male. S. flexneri cases were more likely to attend accident and emergency (46.7% vs. 25.3%, p\u2009=\u20090.005), be admitted to hospital (26.7% vs. 10.7%, p\u2009=\u20090.01), and receive antibiotics (51.1% vs. 28.0%, p\u2009=\u20090.003) compared to S. sonnei cases. Thirty-two (18.9%) patients were admitted to hospital for a median of five\u2009days (IQR 3\u20138). Where recorded 42\/84 (50.0%) reported recent travel. Seventeen (10.1%) patients experienced complications. There were no deaths within one year of diagnosis. Seventy-nine isolates were characterised by WGS. Fifty-seven (72.2%) belonged to known national clusters; 44 (55.7%) involving adult males and 11 (13.9%) travel-associated clusters. We demonstrate the development of severe complications of shigellosis among adults and highlight the changing epidemiology and antibiotic resistance patterns.<\/jats:p>","DOI":"10.1177\/0956462419871851","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T04:06:02Z","timestamp":1574136362000},"page":"1373-1381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Shigellosis in adults: A retrospective study of clinical and epidemiological features in East London"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-4116","authenticated-orcid":false,"given":"Emma","family":"McGuire","sequence":"first","affiliation":[{"name":"Division of Infection, Barts Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Mikhail","sequence":"additional","affiliation":[{"name":"Gastrointestinal Department, National Infection Service, Public Health England, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Day","sequence":"additional","affiliation":[{"name":"Gastrointestinal Bacteria Reference Unit, National infection Service, Public Health England, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Serafino-Wani","sequence":"additional","affiliation":[{"name":"Division of Infection, Barts Health NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Godbole","sequence":"additional","affiliation":[{"name":"Gastrointestinal Department, National Infection Service, Public Health England, London, UK"},{"name":"Gastrointestinal Bacteria Reference Unit, National infection Service, Public Health England, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"bibr1-0956462419871851","volume-title":"CDC yellow book 2018: Health information for international travel","author":"Bowen A.","year":"2017"},{"key":"bibr2-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064097"},{"key":"bibr3-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.04.037"},{"key":"bibr4-0956462419871851","doi-asserted-by":"publisher","DOI":"10.3329\/jhpn.v30i3.12288"},{"key":"bibr5-0956462419871851","first-page":"20137","volume":"17","author":"Borg ML","year":"2012","journal-title":"Euro Surveill"},{"key":"bibr6-0956462419871851","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES2015.20.15.21097"},{"key":"bibr7-0956462419871851","unstructured":"Public Health England (PHE). Epidemiology of Shigella in adults in London, 2011 to 2015: sustained excess in men who have sex with men. PHE gateways number 2016003. 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EUCAST disk diffusion method for Antimicrobial Susceptibility Testing version 7.0, January 2019, http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Disk_test_documents\/2019_manuals\/Manual_v_7.0_EUCAST_Disk_Test_2019.pdf"},{"key":"bibr23-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01790-16"},{"key":"bibr24-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx170"},{"key":"bibr25-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.Supplement_1.S84"},{"key":"bibr26-0956462419871851","doi-asserted-by":"publisher","DOI":"10.3201\/eid0506.990614"},{"key":"bibr27-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis224"},{"key":"bibr28-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112561"},{"key":"bibr29-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370110162025"},{"key":"bibr30-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.4.784"},{"key":"bibr31-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.02.020"},{"key":"bibr32-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2016.11.025"},{"key":"bibr33-0956462419871851","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780361010"},{"key":"bibr34-0956462419871851","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121254"},{"key":"bibr35-0956462419871851","volume-title":"Systematic review on the incubation and infectiousness\/shedding period of communicable diseases in children","author":"European Centre for Disease Prevention and Control","year":"2016"},{"key":"bibr36-0956462419871851","unstructured":"CDC Health Alert Network. 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