{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:25Z","timestamp":1777927285125,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Early syphilis accounts for a large proportion of patients with syphilis. Non- Treponema pallidum tests are commonly used to assess treatment effectiveness by analyzing the serological titer before treatment and six months after treatment. However, serological changes during the first three months after completion of treatment have not been completely understood. This prompted us to investigate whether serum titers of patients exhibit a continuous decrease post-treatment and to assess the trend of change in serological titer during this period. One hundred and seventy-three eligible patients with early syphilis were included in the analysis. Pre-treatment serological titers and those at three and six months post-treatment were compared and analyzed. Serological recovery was defined as a 4-fold or greater decrease in titer from pre-treatment level. Forty patients (23.1%) were found to have an increased serum titer at three months after treatment. Among the 40 patients, 13 patients had primary syphilis, 5 patients had secondary syphilis, and 22 patients had early latent syphilis. The proportion of patients with primary syphilis was higher, and their initial titers were significantly lower. No significant differences were observed with respect to age, gender, or initial treatment. The assessment results of 17 patients (9.8% of the total patients) change. Serological changes in some patients exhibit a parabolic pattern that may affect the clinician\u2019s assessment of patient recovery. Therefore, more frequent assessment of serological titer might be required within the first six months post-treatment.<\/jats:p>","DOI":"10.1177\/0956462419871855","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T03:13:52Z","timestamp":1574219632000},"page":"1389-1396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Post-treatment serological changes in some patients with early syphilis exhibit a parabolic trend"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7514-9297","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology and STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Artificial Cell; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Que-Qiao","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Artificial Cell; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Artificial Cell; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and STD, The Third Central Hospital of Tianjin; Tianjin Key Laboratory of Artificial Cell; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Third Central Hospital of Tianjin, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Third Central Hospital of Tianjin, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"bibr1-0956462419871855","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01095-09"},{"key":"bibr2-0956462419871855","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.048314"},{"key":"bibr3-0956462419871855","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60074-9"},{"key":"bibr4-0956462419871855","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.05.007"},{"key":"bibr5-0956462419871855","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr6404a1","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR Recomm Rep"},{"key":"bibr6-0956462419871855","doi-asserted-by":"publisher","DOI":"10.1177\/0956462415624059"},{"key":"bibr7-0956462419871855","unstructured":"NHC\/MOH. 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