{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:41:57Z","timestamp":1777927317907,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>To evaluate the efficacy and safety of 1% and 5% 5-fluorouracil (5-FU) creams compared with 90% trichloroacetic acid (TCA) for the treatment of anogenital warts. we conducted a randomised controlled study in 72 subjects allocated to three groups: 1% 5-FU, 90% TCA and 5% 5-FU; 90% TCA was administered once a week, whereas 5-FU cream was applied three times a week. Response to therapy and side-effects were evaluated weekly for seven\u2009weeks. Evaluation at week 7 demonstrated that there was no significant difference in the efficacy between 1% 5-FU cream and 90% TCA ( p\u2009= \u20090.763) or between 5% 5-FU cream and 90% TCA ( p\u2009= \u20090.274). Subjective side-effects with 1% 5-FU were significantly milder than 90% TCA; however, significantly milder objective side-effects were observed only at weeks 2, 6 and 7. The subjective side-effects with 5% 5-FU were also significantly milder than 90% TCA; however, significantly milder objective side-effects were observed only at week 2. 5-FU may become an alternative topical therapy as it offers the benefit of self-application; furthermore, a concentration of 1% 5-FU cream is recommended due to milder side-effects.<\/jats:p>","DOI":"10.1177\/0956462420925250","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T03:16:20Z","timestamp":1593573380000},"page":"849-858","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Randomised controlled trial of 1% and 5% 5-fluorouracil creams compared with 90% trichloroacetic acid solution for anogenital wart treatment"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-7125","authenticated-orcid":false,"given":"Ika","family":"Anggraini","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia\u2013Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida Sd","family":"Hoemardani","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Dharmais Cancer National Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-7258","authenticated-orcid":false,"given":"Hanny","family":"Nilasari","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia\u2013Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wresti","family":"Indriatmi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia\u2013Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"bibr1-0956462420925250","first-page":"489","volume-title":"Sexually transmitted diseases","author":"Winer R","year":"2008"},{"key":"bibr2-0956462420925250","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-39"},{"key":"bibr3-0956462420925250","first-page":"521","volume":"52","author":"Taner ZM","year":"2007","journal-title":"J Reprod Med"},{"key":"bibr4-0956462420925250","unstructured":"Clinical effectiveness group British Association for sexual health and HIV. UK national guidelines on the management of anogenital warts 2015. 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