{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:02:51Z","timestamp":1784592171752,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"OPAS \u2013 Organiza\u00e7\u00e3o Panamericana de Sa\u00fade."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Human immunodeficiency virus (HIV) viral load (VL) during pregnancy is a critical determinant of the risk of HIV mother-to-child transmission (MTCT). Prior studies suggest that VL suppression is influenced by antiretroviral regimen. In this study, using secondary real-life data from the Ministry of Health of Brazil, we compared VL suppression at 60\u2013180\u2009days after the first antiretroviral therapy (ART) prescription during pregnancy and time to undetectable VL among pregnant women under treatment with double nucleoside\/nucleotide regimens combined with efavirenz, boosted lopinavir, boosted atazanavir, or raltegravir, with adjustment for potential confounders in multivariable models. A total of 18,997 pregnant women living with HIV were included in the study. Compared to regimens containing lopinavir, we found that atazanavir-, efavirenz-, and raltegravir-based regimens were superior in achieving both outcomes after adjustment for age, social vulnerability index, time under ART, baseline CD4+ cell count, and baseline HIV VL. Raltegravir-containing regimens had the highest adjusted odds\/rates of VL suppression compared to patients with other regimens. Elimination of HIV MTCT is still a critical public health issue in many countries. Our findings suggest that raltegravir-based regimens were superior when compared to efavirenz-, lopinavir-, and atazanavir-based antiretroviral regimens in achieving suppression of HIV VL.<\/jats:p>","DOI":"10.1177\/0956462420932688","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T14:36:16Z","timestamp":1595514976000},"page":"903-910","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of antiretroviral regimen on viral suppression among pregnant women living with HIV in Brazil"],"prefix":"10.1177","volume":"31","author":[{"given":"Ana R Pati","family":"Pascom","sequence":"first","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections, Ministry of Health of Brazil, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda F","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections, Ministry of Health of Brazil, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana Gon\u00e7alves Gon\u00e7alves","family":"Pinho","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections, Ministry of Health of Brazil, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Barros","family":"Perini","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections, Ministry of Health of Brazil, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections, Ministry of Health of Brazil, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-3088","authenticated-orcid":false,"given":"Vivian I","family":"Avelino-Silva","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"bibr1-0956462420932688","first-page":"1715","volume":"61","author":"Mandelbrot L","year":"2015","journal-title":"Clin Infect Dis"},{"key":"bibr2-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-013-0154-z"},{"key":"bibr3-0956462420932688","unstructured":"The Joint United Nations Programme on HIV\/AIDS (UNAIDS). UNAIDS global country fact sheets. www.unaids.org\/en\/resources\/campaigns\/globalplan\/factsheets (accessed 10 April 2019)."},{"key":"bibr4-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12397"},{"key":"bibr5-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001343"},{"key":"bibr6-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-6707-3"},{"key":"bibr7-0956462420932688","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.30.239.14532"},{"key":"bibr8-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30316-3"},{"key":"bibr9-0956462420932688","doi-asserted-by":"crossref","unstructured":"Angulo JMC, Cuesta TAC, Menezes EP, et\u00a0al. A systematic review on the influence of Hla-B polymorphisms on HIV-1 mother-to-child-transmission.\n                      Braz J Infect Dis\n                      2019; 23(1):53\u201359.","DOI":"10.1016\/j.bjid.2018.12.002"},{"key":"bibr10-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000531"},{"key":"bibr11-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1080\/15284336.2018.1459343"},{"key":"bibr12-0956462420932688","volume-title":"Atlas da vulnerabilidade social nos munic\u00edpios brasileiros","author":"Costa M","year":"2015"},{"key":"bibr13-0956462420932688","unstructured":"Mirochnick MS, Shapiro DE,  Morrison L, et al. Randomized trial of Raltegravir-ART vs Efavirenz-ART when initiated during pregnancy. In:\n                      Conference on retroviruses and opportunistic diseases,\n                      Seattle, 4-7 March 2019."},{"key":"bibr14-0956462420932688","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2017.7017"},{"key":"bibr15-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30246-6"},{"key":"bibr16-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1177\/0956462417714094"},{"key":"bibr17-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0107-7"},{"key":"bibr18-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009857"},{"key":"bibr19-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00857.x"},{"key":"bibr20-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199906180-00014"},{"key":"bibr21-0956462420932688","doi-asserted-by":"publisher","DOI":"10.1086\/339074"},{"key":"bibr22-0956462420932688","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Doen\u00e7as de Condi\u00e7\u00f5es Cr\u00f4nicas e Infec\u00e7\u00f5es Sexualmente Transmiss\u00edveis. Protocolo Cl\u00ednico e Diretrizes Terap\u00eauticas para Preven\u00e7\u00e3o da Transmiss\u00e3o Vertical do HIV, S\u00edfilis e Hepatites Virais. Brasilia, Brazil, 2019."},{"key":"bibr23-0956462420932688","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Programa Nacional de DST e Aids. Recomenda\u00e7\u00f5es para Profilaxia da Transmis\u00e3o Vertical do HIV e Terapia Antirretroviral em Gestantes: manual de bolso. Brasilia, Brazil, 2010."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462420932688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462420932688","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462420932688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:40:50Z","timestamp":1777675250000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462420932688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/0956462420932688"],"URL":"https:\/\/doi.org\/10.1177\/0956462420932688","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]}}}