{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:42:05Z","timestamp":1777927325690,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100022752","name":"MSD Sharp & Dohme GmbH","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100022752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Due to demographic changes in people living with HIV (PLHIV), physicians are challenged with age-related comorbidities and their management. In the absence of comprehensive data collection, the burden of comorbidities and co-medication in addition to antiretroviral therapy (ART) remains unclear for the German real-world setting. BESIDE was an observational, cross-sectional study evaluating the prevalence of comorbidities and use of co-medication in treated PLHIV. Regional distribution of study centers (n\u2009=\u200920), consecutive patient recruitment, and age-stratified sampling in alignment with national epidemiologic data aimed to ensure a representative sample (n\u2009=\u2009453). The overall prevalence of comorbidities was 91.2%; 31.6% of patients had \u22654 comorbidities. The most common diagnoses were vitamin D deficiency (29.1%), depressive episode (27.8%), arterial hypertension (16.3%), and hypercholesterolemia (10.8%). 83.7% of patients were on co-medication; 21.2% taking \u22654 medications. The most common medications or supplements were vitamins (31.6%), anti-inflammatory agents (16.1%), renin\u2013angiotensin system agents (12.1%), acid suppressants (11.7%), lipid modifying agents (10.8%); 1.3% of patients were on co-medication that should not be co-administered with ART, 41.5% on co-medication with potential for drug\u2013drug interactions. The prevalence of comorbidities and use of co-medication among treated PLHIV in Germany is consistently high and increases across age groups, illustrating the complexity of HIV care involving appropriate ART selection.<\/jats:p>","DOI":"10.1177\/0956462420942020","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T02:33:08Z","timestamp":1608085988000},"page":"152-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["High prevalence of comorbidities and use of concomitant medication in treated people living with HIV in Germany \u2013 results of the BESIDE study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-3753","authenticated-orcid":false,"given":"B","family":"Funke","sequence":"first","affiliation":[{"name":"MSD Sharp & Dohme GmbH, Medical Affairs, Haar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CD","family":"Spinner","sequence":"additional","affiliation":[{"name":"Technical University of Munich, School of Medicine, University Hospital Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Wolf","sequence":"additional","affiliation":[{"name":"MUC Research, Munich, Germany"},{"name":"MVZ Karlsplatz, HIV Research and Clinical Care Centre, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Heiken","sequence":"additional","affiliation":[{"name":"Praxis Georgstrasse, Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Christensen","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Medicine (CIM) Infectious Diseases, Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HJ","family":"Stellbrink","sequence":"additional","affiliation":[{"name":"Infectiology Center Hamburg (ICH), Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Witte","sequence":"additional","affiliation":[{"name":"MSD Sharp & Dohme GmbH, Medical Affairs, Haar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"bibr1-0956462420942020","unstructured":"UNAIDS. 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