{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:15:38Z","timestamp":1792134938697,"version":"4.4.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011314","name":"Sir John Fisher Foundation","doi-asserted-by":"publisher","award":["Not available"],"award-info":[{"award-number":["Not available"]}],"id":[{"id":"10.13039\/100011314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011319","name":"Skin Treatment and Research Trust","doi-asserted-by":"crossref","award":["Not available"],"award-info":[{"award-number":["Not available"]}],"id":[{"id":"10.13039\/100011319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>The pathogenesis of male genital lichen sclerosus (MGLSc) is controversial. Incriminated factors include infection with human papillomavirus (HPV) and autoimmunity (e.g. Human Leukocyte Antigen [HLA]). To address the roles of HLA and HPV in MGLSc we studied adult Caucasian males with a clinical and histological diagnosis of MGLSc. The men in the study attended two specialised Male Genital Dermatoses Clinics between July 2011 and September 2012 and were selected and phenotyped from the clinical records. DNA was extracted from blood and paraffin-embedded biopsy sections, for HLA and HPV typing, respectively. HLA allele frequencies were compared with those derived from the UK-based Caucasian population. Eighty-eight cases of MGLSc were identified. HPV DNA was detected in 33\/88 (37.5%) cases of MGLSc. HPV16 was the most prevalent type found: 11\/88 (12.5%) MGLSc. No statistically significant HLA associations were established but HLA-B*35, -B*51, -C*15, -DRB1*04, -DRB1*10 (predisposition) and -DQA1*01 (protection) were revealed as alleles of interest. HPV16-associated MGLSc cases showed no statistically significant association with HLA genotype. The relationship between HPV and MGLSc suggests a passenger effect rather than a pathogenic role. HLA is not associated with MGLSc nor co-existent HPV16.<\/jats:p>","DOI":"10.1177\/0956462420949395","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T03:12:06Z","timestamp":1603249926000},"page":"1334-1339","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Immunogenetics and human papillomavirus (HPV) in male genital lichen sclerosus (MGLSc)"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-9811","authenticated-orcid":false,"given":"Tang Ngee","family":"Shim","sequence":"first","affiliation":[{"name":"Dermatology Department, University College Hospital, Chelsea and Westminster Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A","family":"Harwood","sequence":"additional","affiliation":[{"name":"Center for Cutaneous Research and Cell Biology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven GE","family":"Marsh","sequence":"additional","affiliation":[{"name":"Anthony Nolan Research Institute, University College London Cancer Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M","family":"Gotch","sequence":"additional","affiliation":[{"name":"Immunology Department, Imperial College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Quint","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory, Rijswijk, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurits N","family":"de Koning","sequence":"additional","affiliation":[{"name":"DDL Diagnostic Laboratory, Rijswijk, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Francis","sequence":"additional","affiliation":[{"name":"Pathology Department, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Jameson","sequence":"additional","affiliation":[{"name":"Pathology Department, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Freeman","sequence":"additional","affiliation":[{"name":"Pathology Department, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suks","family":"Minhas","sequence":"additional","affiliation":[{"name":"Andrology Centre and the Institute of Urology, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dinneen","sequence":"additional","affiliation":[{"name":"Urology Department, Chelsea and Westminster Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Muneer","sequence":"additional","affiliation":[{"name":"Andrology Centre and the Institute of Urology, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B","family":"Bunker","sequence":"additional","affiliation":[{"name":"Dermatology Department, University College Hospital, Chelsea and Westminster Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.152501"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00572.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb02831.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12329"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03360.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05013.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23905.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02611.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07961.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103710"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02122-09"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65688-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.8.2508-2517.1999"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.5.1792-1800.2006"},{"key":"e_1_3_2_16_2","volume-title":"DNeasy blood & tissue handbook 07\/2006","author":"Qiagen","year":"2006","unstructured":"Qiagen. 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