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Human papillomavirus (HPV) vaccination has shown very high protection rates against AGWs in clinical trials and real-world settings but vaccination coverage remains low in many countries. The aim of this review is to summarize the current evidence on the risk factors for AGW development and to present the available real-life data on the impact of HPV vaccination on AGW incidence. An increased number of lifetime sexual partners, a new sexual partner in the last 12\u2009months, smoking, and immunosuppression have been associated with increased risk for AGWs. HPV vaccination has led to a dramatic decline in AGW incidence in populations that have achieved high vaccination rates. These conclusions can contribute to primary prevention of AGWs and evidence-based counselling of AGW patients.<\/jats:p>","DOI":"10.1177\/0956462420958577","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T02:57:10Z","timestamp":1604977030000},"page":"4-13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Incidence of anogenital warts: epidemiological risk factors and real-life impact of human papillomavirus vaccination"],"prefix":"10.1177","volume":"32","author":[{"given":"Georgios","family":"Tyros","sequence":"first","affiliation":[{"name":"1st Department of Dermatology and Venereology, Medical School, National and Kapodistrian University of Athens, \u201cA. 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