{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:42:33Z","timestamp":1777927353439,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>We evaluated the ResistancePlus\u00ae MG assay in providing macrolide resistance-guided treatment (RGT) for Mycoplasma genitalium infection at a UK sexual health centre. M. genitalium\u2013positive samples from men with urethritis and women with pelvic inflammatory disease (PID) were tested for macrolide resistance\u2013mediating mutations (MRMMs). MRMM-positive infections were given moxifloxacin 400\u00a0mg; otherwise 2\u00a0g azithromycin (1\u00a0g single dose and then 500\u00a0mg OD) was given. Among 57\u00a0 M. genitalium\u2013positive patients (32 men and 25 women), MRMMs were detected in 41\/57 (72% [95% confidence interval (95% CI) 58\u201383%). Thirty-two of 43 patients given RGT attended for test of cure. Treatment failure rate was significantly lower at 1\/32 (3%) than 10\/37 (27%) before RGT ( n = 37 [men = 23 and women = 17]; p = 0.008). Treatment failure was lower in male urethritis (0\/15 vs. 7\/21 p = 0.027) but not in female PID. There was a trend of a shorter time to negative test of cure (TOC) in male urethritis (55.1 [95% 43.7\u201366.4] vs. 85.1 [95% CI CI 64.1\u2013106.0] days, p = 0.077) but not in female PID. Macrolide resistance is higher than previous UK reports and higher than expected. RGT reduces overall treatment failure and is particularly beneficial in M. genitalium urethritis. Fluoroquinolone resistance will continue to rise with increasing fluoroquinolone use, and RGT is critical to direct appropriate azithromycin use and prevent overuse of moxifloxacin.<\/jats:p>","DOI":"10.1177\/0956462420987764","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T12:54:03Z","timestamp":1616504043000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Resistance-guided treatment of\n                    <i>Mycoplasma genitalium<\/i>\n                    infection at a UK sexual health centre"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0025-7060","authenticated-orcid":false,"given":"Ruairi JH","family":"Conway","sequence":"first","affiliation":[{"name":"Department of Medicine, Brighton and Sussex Medical School, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4596-1916","authenticated-orcid":false,"given":"Seamus","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brighton and Sussex Medical School, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0704-8018","authenticated-orcid":false,"given":"Simon","family":"Bone","sequence":"additional","affiliation":[{"name":"SpeeDx Pty Ltd, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Osman","family":"Hassan-Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suneeta","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brighton and Sussex Medical School, Brighton, UK"},{"name":"Department of Sexual Health and HIV, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"bibr1-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-11"},{"key":"bibr2-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ312"},{"key":"bibr3-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054386"},{"key":"bibr4-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2020-054511"},{"key":"bibr5-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054335"},{"key":"bibr6-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit752"},{"key":"bibr7-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30154-7"},{"key":"bibr8-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy477"},{"key":"bibr9-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061481"},{"key":"bibr10-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00495-13"},{"key":"bibr11-0956462420987764","unstructured":"European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products, https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/quinolone-fluoroquinolone-containing-medicinal-products (accessed 10 Jan 2019)."},{"key":"bibr12-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1177\/0956462419825948"},{"key":"bibr13-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1031"},{"key":"bibr14-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054064"},{"issue":"6","key":"bibr15-0956462420987764","doi-asserted-by":"crossref","first-page":"e0156740","DOI":"10.1371\/journal.pone.0156740","volume":"11","author":"Soni SN","year":"2016","journal-title":"PLoS One"},{"key":"bibr16-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu1162"},{"key":"bibr17-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-052718.6"},{"key":"bibr18-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-053060"},{"key":"bibr19-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy843"},{"key":"bibr20-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv246"},{"key":"bibr21-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ644"},{"issue":"11","key":"bibr22-0956462420987764","first-page":"e00886","volume":"57","author":"Fairley M","year":"2019","journal-title":"J Clin Microbiol"},{"key":"bibr23-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001095"},{"key":"bibr24-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz550"},{"key":"bibr25-0956462420987764","doi-asserted-by":"publisher","DOI":"10.3201\/eid2402.170902"},{"key":"bibr26-0956462420987764","doi-asserted-by":"publisher","DOI":"10.1080\/13691058.2010.535018"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462420987764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0956462420987764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0956462420987764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:41:48Z","timestamp":1777675308000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0956462420987764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/0956462420987764"],"URL":"https:\/\/doi.org\/10.1177\/0956462420987764","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}