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Empirical treatment should be started in patients with objective swelling and tenderness on testicular examination. First-line empirical treatment for sexually acquired epididymo-orchitis has changed to ceftriaxone 1g intramuscularly and doxycycline. Higher dose of ceftriaxone in line with the BASHH 2018 gonorrhoea guideline ensures effective treatment of strains with reduced susceptibility. Ofloxacin or doxycycline is recommended in patients with epididymo-orchitis probably due to non-gonococcal organisms (e.g. negative microscopy for gram-negative intracellular diplococci or no risk factors for gonorrhoea identified). Where Mycoplasma genitalium is tested and identified, treatment should include an appropriate antibiotic (e.g. moxifloxacin). If enteric pathogens are a likely cause (e.g. older patient, not sexually active, recent instrumentation, men who practice insertive anal intercourse, men with known abnormalities of the urinary tract or a positive urine dipstick for leucocytes and nitrites), ofloxacin and levofloxacin are recommended. A clinical care pathway has been produced to simplify the management of epididymo-orchitis. A patient information leaflet has been developed.<\/jats:p>","DOI":"10.1177\/09564624211003761","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T11:10:16Z","timestamp":1621422616000},"page":"884-895","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["United Kingdom British association for sexual health and HIV national guideline for the management of epididymo-orchitis, 2020"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-7650","authenticated-orcid":false,"given":"Mimie","family":"Chirwa","sequence":"first","affiliation":[{"name":"Genitourinary Medicine, Bedfordshire Hospitals NHS Foundation Trust, Luton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olubanke","family":"Davies","sequence":"additional","affiliation":[{"name":"Genitourinary Medicine, Epsom & St Helier University Hospitals NHS Trust, London, 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