{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:42:42Z","timestamp":1777927362205,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n                    Early diagnosis and treatment of incident cases of hepatitis C virus (HCV) infection is fundamental to eliminate HCV in HIV-positive patients. From January 2016 to December 2019, we attended 40 episodes of acute HCV infection (AHC) in 35 subjects (9 reinfections) who were coinfected with HIV. The patients were treated with direct-acting antiviral agents (DAAs) in seven hospitals in Andalusia, Spain. All were men who have sex with men (MSM), mean age was 42.9 (\u00b18.3) years and median time of HIV infection was 46.6\u00a0months (IQR: 20.4\u201367.2). All received antiretroviral therapy and had undetectable HIV viral load (except 2 with 65 and 68 copies\/mL); median CD4 count was 632 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    (IQR: 553\u2013896). Over half (74.3%) also had another concomitant sexually transmitted infection, syphilis (48.6%) being the most common. AHC was asymptomatic in 32 cases (80%). Genotypic distribution was G1a 65%, G4 32.5% and G1b 3%. Median time to DAA was 6\u00a0weeks (IQR: 4.3\u201318.3) and median baseline HCV RNA was 6.1 Log (IQR: 5.6\u20136.5). DAA regimens were SOF\/LDV (19 episodes), SOF\/VEL (14), ELB\/GZV (5) and GLP\/PIB (2). All presented sustained viral response and none discontinued due to adverse effects. In conclusion, early treatment with DAA in AHC patients proved effective and safe. It could be an excellent strategy to eliminate HCV infection in HIV-coinfected MSM.\n                  <\/jats:p>","DOI":"10.1177\/09564624211033756","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T03:30:55Z","timestamp":1627011055000},"page":"1257-1260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute hepatitis C virus infection and direct-acting antiviral drugs: Perfect combination to eliminate the epidemic?"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-2355","authenticated-orcid":false,"given":"Cristina","family":"G\u00f3mez-Ayerbe","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Hospital Universitario Virgen de la Victoria, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Palacios","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Hospital Universitario Virgen de la Victoria, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen Macarena, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"T\u00e9llez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina, Universidad de C\u00e1diz, Hospital Universitario de Puerto Real, Puerto Real, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Sayago","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3086-9095","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Mart\u00edn-Aspas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta del Mar, C\u00e1diz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Camacho","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Cecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Hospital Universitario Virgen de la Victoria, M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"HEPAVIR Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"bibr1-09564624211033756","unstructured":"Fanciulli C, Berenguer J, Busca C, et al. HIV\/HCV coinfection in spain: trouble will soon be over. Toledo: XI Congreso Nacional GeSIDA, 2019, pp. 10\u201313."},{"key":"bibr2-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx258"},{"key":"bibr3-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0026-5"},{"key":"bibr4-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000834"},{"key":"bibr5-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0975-y"},{"key":"bibr6-09564624211033756","first-page":"440","volume":"32","author":"Lozano Rinc\u00f3n EE","year":"2019","journal-title":"Rev Esp Quimioter"},{"key":"bibr7-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328343443b"},{"key":"bibr8-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619835394"},{"key":"bibr9-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13039"},{"key":"bibr10-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"bibr11-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31060"},{"key":"bibr12-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12600"},{"key":"bibr13-09564624211033756","unstructured":"Boesecke C, M\u00fcller Mart\u00ednez E, Nelson M, et al. Fueling the epidemic: low rates of spontaneous clearance of acute HCV coinfection. In: 25th conference on retroviruses and opportunistic infections (CROI), Boston, MA, 4\u20137 March 2018."},{"key":"bibr14-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30408-X"},{"key":"bibr15-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30003-1"},{"key":"bibr16-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy913"},{"key":"bibr17-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1071\/SH16141"},{"key":"bibr18-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.038"},{"key":"bibr19-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1007"},{"key":"bibr20-09564624211033756","unstructured":"Braun DL, Hampel BH, Nguyen H, et al. Swiss HIV cohort study. A treatment as prevention trial to eliminate HCV in HIV+ MSM: the swiss HCV free trial. In: 25th conference on retroviruses and oppor\u2013tunistic Infections (CROI), Boston, MA; 4\u20137 March 2018."},{"key":"bibr21-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz367"},{"key":"bibr22-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210179"},{"key":"bibr23-09564624211033756","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619843735"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624211033756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624211033756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624211033756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:42:08Z","timestamp":1777675328000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624211033756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":23,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/09564624211033756"],"URL":"https:\/\/doi.org\/10.1177\/09564624211033756","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]}}}