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We report a patient with a documented history of metronidazole hypersensitivity who initially was treated with nitazoxanide but demonstrated clinical and microbiological failure. Secnidazole was subsequently used for treatment, which resulted in clinical and microbiological cure without observation of cross-reactivity. Secnidazole may represent a potential treatment option for trichomoniasis in patients with metronidazole hypersensitivity after consultation with an infectious disease specialist.<\/jats:p>","DOI":"10.1177\/09564624211034974","type":"journal-article","created":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T03:39:31Z","timestamp":1628998771000},"page":"1271-1273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment with secnidazole for trichomoniasis in the setting of metronidazole hypersensitivity"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7703-096X","authenticated-orcid":false,"given":"Wesley D","family":"Kufel","sequence":"first","affiliation":[{"name":"Binghamton University School of Pharmacy and Pharmaceutical Sciences, Binghamton, NY, USA"},{"name":"State University of New York Upstate Medical University, Syracuse, NY, USA"},{"name":"State University of New York Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Asiago-Reddy","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University, Syracuse, NY, USA"},{"name":"State University of New York Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie A","family":"Parsels","sequence":"additional","affiliation":[{"name":"State University of New York Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soma","family":"Sanyal","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University, Syracuse, NY, USA"},{"name":"State University of New York Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L","family":"Coyne","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University, Syracuse, NY, USA"},{"name":"State University of New York Upstate University Hospital, Syracuse, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"bibr1-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318286bb53"},{"key":"bibr2-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ738"},{"key":"bibr3-09564624211034974","author":"Van Gerwen OT","year":"2020","journal-title":"Sex Transm Dis"},{"key":"bibr4-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000618"},{"key":"bibr5-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.10.795"},{"issue":"3","key":"bibr6-09564624211034974","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1159\/000017913","volume":"196","author":"Thami GP","year":"1998","journal-title":"Dermatology"},{"key":"bibr7-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2016.12.014"},{"key":"bibr8-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e31802f5d9a"},{"key":"bibr9-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02329-17"},{"key":"bibr10-09564624211034974","volume-title":"Lupin Presents Phase 3 Data for Solosec (Secnidazole) Demonstrating Significant Response Rate in Female Patients with Trichomoniasis","author":"BioSpace","year":"2020"},{"key":"bibr11-09564624211034974","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03651.x"},{"key":"bibr12-09564624211034974","volume-title":"Metronidazole [package insert]","year":"2021"},{"key":"bibr13-09564624211034974","volume-title":"Secnidazole [package insert]","year":"2021"},{"key":"bibr14-09564624211034974","volume-title":"Tinidazole [package insert]","year":"2019"}],"container-title":["International Journal of STD &amp; 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