{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:21:34Z","timestamp":1785781294579,"version":"3.56.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections are common among men who have sex with men (MSM). Many oropharyngeal and anorectal infections remain asymptomatic. We aimed to evaluate triple-site screening following PrEP introduction. We enrolled a prospective cohort study including 210 asymptomatic MSM during 2019\u20132020, analyzed by groups: HIV positive (HIV+), HIV\u2212uninfected using PrEP (HIV\u2212\/PrEP+), or HIV-uninfected not using PrEP (HIV\u2212\/PrEP\u2212). A self-administered questionnaire captured demographic information and sexual risk-taking behaviors. CT\/NG testing results were compared between study groups and predictors of infection were evaluated. We included 59 HIV+, 70 HIV\u2212\/PrEP+, and 81 HIV\u2212\/PrEP\u2212 subjects. 30% ( n = 62) of participants tested positive for CT\/NG. HIV\u2212\/PrEP+ group had highest proportion of infections ( n = 33, 47%) followed by HIV\u2212\/PrEP\u2212 ( n = 16, 22%) and HIV+ ( n=13, 20%; p &lt; .001). Importantly, 98% (80\/82) of pharyngeal\/anorectal CT\/NG infections were missed in genitourinary tract screening alone. PrEP use and previous syphilis infection were the strongest risk factor for CT\/NG. Extra-genital asymptomatic CT\/NG infections were prevalent among MSM. These data highlight the importance of routine extra-genital CT\/NG testing in asymptomatic sexually active MSM. The study describes the consequences for three-site testing lack of implementation in the PrEP era.<\/jats:p>","DOI":"10.1177\/09564624211047477","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T05:32:28Z","timestamp":1634880748000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Triple site sexually transmitted infection testing as a crucial component of surveillance for men who have sex with men: A prospective cohort study"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-7433","authenticated-orcid":false,"given":"Roy","family":"Zucker","sequence":"first","affiliation":[{"name":"Crusaid Kobler AIDS Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"},{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-1382","authenticated-orcid":false,"given":"Michael","family":"Gaisa","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sigel","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Singer","sequence":"additional","affiliation":[{"name":"Crusaid Kobler AIDS Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos","family":"Adler","sequence":"additional","affiliation":[{"name":"Crusaid Kobler AIDS Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Turner","sequence":"additional","affiliation":[{"name":"Crusaid Kobler AIDS Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Ben Ami","sequence":"additional","affiliation":[{"name":"Crusaid Kobler AIDS Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Nissan","sequence":"additional","affiliation":[{"name":"Ministry of Health, National Public Health Laboratory, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Chan","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Halperin","sequence":"additional","affiliation":[{"name":"Crusaid Kobler AIDS Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"bibr1-09564624211047477","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2947"},{"key":"bibr2-09564624211047477","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001185"},{"key":"bibr3-09564624211047477","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001718"},{"key":"bibr4-09564624211047477","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1085"},{"issue":"03","key":"bibr5-09564624211047477","first-page":"1","volume":"64","author":"Workowski KA","year":"2015","journal-title":"MMWR Recomm 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for Disease Control and Prevention (CDC). Sexually transmitted disease surveillance, 2018, https:\/\/www.cdc.gov\/std\/stats18\/default.htm."},{"key":"bibr25-09564624211047477","unstructured":"US Food and Drug Administration (FDA). FDA clears first diagnostic tests for extragenital testing for chlamydia and gonorrhea [FDA news release], https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-clears-firstdiagnostic-tests-extragenital-testing-chlamydia-and-gonorrhea (accessed 23 May 2019)."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624211047477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624211047477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624211047477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:42:20Z","timestamp":1777675340000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624211047477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/09564624211047477"],"URL":"https:\/\/doi.org\/10.1177\/09564624211047477","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,22]]}}}