{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:42:57Z","timestamp":1777927377052,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005192","name":"California HIV\/AIDS Research Program","doi-asserted-by":"publisher","award":["EI-11-SD-005"],"award-info":[{"award-number":["EI-11-SD-005"]}],"id":[{"id":"10.13039\/100005192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005192","name":"California HIV\/AIDS Research Program","doi-asserted-by":"publisher","award":["MC08-SD-700"],"award-info":[{"award-number":["MC08-SD-700"]}],"id":[{"id":"10.13039\/100005192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI 36214"],"award-info":[{"award-number":["AI 36214"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K01AI136725"],"award-info":[{"award-number":["K01AI136725"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI007384"],"award-info":[{"award-number":["T32AI007384"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HIV PrEP effectiveness is highly dependent on adherence. High STI incidence has been reported among PrEP users. We assessed the relationship between STI incidence (CT, NG, and syphilis) and PrEP adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a subanalysis of a controlled, open-label, two-arm, randomized clinical demonstration project of a text-message based adherence intervention. Participants had 48\u00a0weeks of follow-up and had STI testing every 12 or 24\u00a0weeks. PrEP adherence was measured at week 48 using intracellular tenofovir-diphosphate drug concentrations. We calculated incidence rate ratios for STIs among those adherent as compared with those not adherent to PrEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 381 assessed for CT, NG and syphilis at one or more follow-up visits, there were 16 cases of syphilis or 5.0 per 100 person years (95% CI: 2.6, 7.5); 63 cases of NG or 26.3 per 100 person years (95% CI: 19.8, 32.8); and 81 cases of CT or 36.3 per 100 person years (95% CI: 28.4, 44.2). We found no association between adequate PrEP adherence and STI incidence (aIRR: 0.97 95% CI: 0.67, 1.40).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that the incidence of STIs was not significantly different between those adherent to PrEP and those non-adherent. Further research is needed to assess how PrEP use may impact STIs over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624211053428","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T13:59:55Z","timestamp":1646315995000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Sexually transmitted infections among participants in an HIV PrEP adherence trial"],"prefix":"10.1177","volume":"33","author":[{"given":"Claire C","family":"Bristow","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adiba","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"},{"name":"Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P","family":"Dub\u00e9","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Corado","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-3233","authenticated-orcid":false,"given":"Karen","family":"Chow","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Ellorin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Blumenthal","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheldon R","family":"Morris","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The CCTG Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"bibr1-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"bibr2-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"bibr3-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"bibr4-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2591"},{"key":"bibr5-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2947"},{"key":"bibr6-09564624211053428","unstructured":"Service UPH. Preexposure prophylaxis for the prevention of HIV infection in the United States - 2017 update clinical practice guideline. 2017. https:\/\/www.cdc.gov\/hiv\/pdf\/risk\/prep\/cdc-hiv-prep-guidelines-2017.pdf."},{"key":"bibr7-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.4683"},{"key":"bibr8-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-016-0089-8"},{"key":"bibr9-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000001185"},{"key":"bibr10-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix439"},{"key":"bibr11-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1001\/virtualmentor.2014.16.11.stas1-1411"},{"key":"bibr12-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu266"},{"key":"bibr13-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004006"},{"key":"bibr14-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy182"},{"key":"bibr15-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2020.1810618"},{"key":"bibr16-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001604"},{"key":"bibr17-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-020-02881-7"},{"key":"bibr18-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1055"},{"key":"bibr19-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2012.0089"},{"key":"bibr20-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000001718"},{"key":"bibr21-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2017-053377"},{"key":"bibr22-09564624211053428","volume-title":"Sexually Transmitted Disease Surveillance 2018","author":"Prevention\u2019 CfDCa","year":"2019"},{"key":"bibr23-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001100"},{"key":"bibr24-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3180415dd7"},{"key":"bibr25-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2009.09.002"},{"key":"bibr26-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2004.010355"},{"key":"bibr27-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-019-01478-z"},{"key":"bibr28-09564624211053428","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-018-2139-9"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624211053428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624211053428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624211053428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:42:36Z","timestamp":1777675356000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624211053428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/09564624211053428"],"URL":"https:\/\/doi.org\/10.1177\/09564624211053428","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}