{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:32:33Z","timestamp":1791952353371,"version":"4.3.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>AIDS-related cytomegalovirus (CMV) encephalitis has declined in the combined antiretroviral therapy (ART) era in high-income countries. However, there is scarce information on CMV encephalitis in low- and middle-income countries. The objectives of this study were to identify the prevalence of AIDS-related CMV encephalitis and describe its main features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a retrospective cohort study carried out at a referral center in S\u00e3o Paulo, Brazil. We included adult people living with HIV\/AIDS (PLWHA), hospitalized in 2019, with a CD4 cell count \u2264100\/mm\n                      <jats:sup>3<\/jats:sup>\n                      and quantitation CMV DNA results in plasma. Cases with compatible neurological manifestations and detection of CMV DNA by polymerase chain reaction (PCR) in cerebrospinal fluid samples were defined as CMV encephalitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 761 PLWHA hospitalized, 248 (32.5%) cases were included in this study. Prevalence of CMV encephalitis was 2.4% (6\/248) among all included cases and 7.7% (6\/78) among individuals with neurological opportunistic diseases. The six patients with CMV encephalitis were males and had CD4 cell count &lt;50\/mm\n                      <jats:sup>3<\/jats:sup>\n                      . Five (83%) cases had CMV encephalitis as AIDS-defining disease and showed CMV DNA detection by PCR &gt;50,000\u00a0UI\/mL plasma. All six cases received anti-CMV therapy (ganciclovir, n = 4; ganciclovir plus foscarnet, n = 2) and five were discharged to home. CMV encephalitis was not uncommon among hospitalized PLWHA with neurological opportunistic diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The epidemiological and immunological profile of individuals with CMV encephalitis was similar to that described in the pre-ART era, but in contrast, most cases were treated and discharged from the hospital.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624221124697","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T02:49:27Z","timestamp":1662518967000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["AIDS-related cytomegalovirus encephalitis in the late ART era: A retrospective cohort study at a referral center in Brazil"],"prefix":"10.1177","volume":"34","author":[{"given":"Rodovaldo M","family":"Lucas J\u00fanior","sequence":"first","affiliation":[{"name":"Departamento de Infectologia, Instituto de Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliane","family":"Bogoni","sequence":"additional","affiliation":[{"name":"Departamento de Infectologia, Instituto de Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A","family":"Reis Schneider","sequence":"additional","affiliation":[{"name":"Departamento de Infectologia, Instituto de Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidyanara F","family":"Castanheira de Souza","sequence":"additional","affiliation":[{"name":"Departamento de Infectologia, Instituto de Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Kassab","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Infectologia, Pontif\u00edcia Universidade Cat\u00f3lica de Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-8716","authenticated-orcid":false,"given":"Jos\u00e9 Ernesto","family":"Vidal","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Instituto de Infectologia Em\u00edlio Ribas, S\u00e3o Paulo, Brazil"},{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias, Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica (LIM 49) da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"bibr1-09564624221124697","first-page":"250","volume":"30","author":"Centers for Disease Control (CDC)","year":"1981","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr2-09564624221124697","first-page":"334","volume":"35","author":"Centers for Disease Control (CDC)","year":"1986","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr3-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.6.1223"},{"key":"bibr4-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.1071"},{"key":"bibr5-09564624221124697","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317120-00002"},{"key":"bibr6-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198711000-00001"},{"key":"bibr7-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199610090-00004"},{"key":"bibr8-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-004-1160-2"},{"key":"bibr9-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1080\/13550280500513846"},{"key":"bibr10-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5189-5198.2004"},{"key":"bibr11-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"bibr12-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80012-6"},{"key":"bibr13-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687080"},{"key":"bibr14-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90293-X"},{"key":"bibr15-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1992.tb00815.x"},{"key":"bibr16-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000245"},{"key":"bibr17-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200210010-00007"},{"key":"bibr18-09564624221124697","first-page":"186850","volume":"2012","author":"Silva AC","year":"2012","journal-title":"AIDS Res Treat"},{"key":"bibr19-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822006000200002"},{"key":"bibr20-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652008000400004"},{"issue":"1","key":"bibr21-09564624221124697","first-page":"23","volume":"15","author":"Vidal JE","year":"2011","journal-title":"Braz J Infect Dis"},{"key":"bibr22-09564624221124697","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/25787489.2021.1975609","volume":"22","author":"Telles JP","year":"2021","journal-title":"HIV Res Clin Pract"},{"key":"bibr23-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.4.747"},{"key":"bibr24-09564624221124697","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-7-199610010-00008"},{"key":"bibr25-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1080\/003655401317074572"},{"key":"bibr26-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098666"},{"key":"bibr27-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1995.tb01495.x"},{"key":"bibr28-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-127"},{"key":"bibr29-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13115"},{"key":"bibr30-09564624221124697","doi-asserted-by":"publisher","DOI":"10.3109\/00365549509019000"},{"key":"bibr31-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.03.005"},{"key":"bibr32-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652010000600004"},{"key":"bibr33-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1101"},{"key":"bibr34-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00900.x"},{"key":"bibr35-09564624221124697","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00899.x"},{"key":"bibr36-09564624221124697","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20623"},{"key":"bibr37-09564624221124697","first-page":"116","volume":"23","author":"Masur H","year":"2015","journal-title":"Top Antivir Med"}],"updated-by":[{"DOI":"10.1177\/09564624221133243","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000}}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624221124697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624221124697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624221124697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:43:48Z","timestamp":1777675428000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624221124697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1177\/09564624221124697"],"URL":"https:\/\/doi.org\/10.1177\/09564624221124697","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]}}}