{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:14:11Z","timestamp":1782281651445,"version":"3.54.5"},"reference-count":65,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program-Youth Medical Talents, Clinical Pharmacist Program","award":["SHWSRS(2021)_099"],"award-info":[{"award-number":["SHWSRS(2021)_099"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tuberculosis (TB) is the leading opportunistic infection of people living with human immunodeficiency virus (HIV; PLWH). Cytochrome P450 (CYP) 2B6 and ATP-binding cassette sub-family B member 1 ( ABCB1) are involved in the metabolism and transportation of efavirenz. The study was aimed to investigate the effects of rifampicin, CYP2B6 and ABCB1 polymorphisms on efavirenz exposure in Chinese PLWH co-infected with TB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      PLWH were screened according to inclusion and exclusion criteria and divided into HIV group and HIV\/TB group. Efavirenz plasma concentration (C\n                      <jats:sub>0<\/jats:sub>\n                      ) was determined, dose-adjusted concentration (C\n                      <jats:sub>0<\/jats:sub>\n                      \/D) was calculated, and genotypes of CYP2B6 516G&gt;T, 785A&gt;G, and ABCB1 2677G&gt;T, 3435C&gt;T were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      252 PLWH were enrolled, including 75 co-infected with TB and concomitant with rifampicin. Efavirenz C\n                      <jats:sub>0<\/jats:sub>\n                      and C\n                      <jats:sub>0<\/jats:sub>\n                      \/D were both higher in HIV group (1.94\u00a0\u03bcg\/mL, 0.2007 (\u03bcg\/ml)\/(mg\/kg\/d)) compared with HIV\/TB group (1.52\u00a0\u03bcg\/mL, 0.1557 (\u03bcg\/ml)\/(mg\/kg\/d)) ( p = .001). Efavirenz C\n                      <jats:sub>0<\/jats:sub>\n                      \/D was significantly higher in patients with variant genotypes of CYP2B6 516G&gt;T and 785A&gt;G ( p&lt;.001), and was significantly lower in HIV\/TB group compared with HIV group among patients with CYP2B6 516\u00a0GG, TT, and 785 AA, AG genotypes ( p &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Efavirenz exposure is reduced by co-administration with rifampicin, and related to genetic polymorphisms of CYP2B6.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624221134137","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T20:38:38Z","timestamp":1668112718000},"page":"37-47","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of rifampicin,\n                    <i>CYP2B6<\/i>\n                    and\n                    <i>ABCB1<\/i>\n                    polymorphisms on efavirenz plasma concentration in Chinese patients living with HIV and tuberculosis"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-467X","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Huashan Hospital Fudan University, Shanghai, People\u2019s Republic of China"},{"name":"Department of Pharmacy, Shanghai Public Health Clinical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai Public Health Clinical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai Public Health Clinical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangkai","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Shanghai Public Health Clinical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Shanghai Public Health Clinical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Huashan Hospital Fudan University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"bibr1-09564624221134137","volume-title":"Global tuberculosis report 2021","author":"Web of World Health Organization","year":"2021"},{"key":"bibr2-09564624221134137","doi-asserted-by":"publisher","DOI":"10.7448\/ias.19.1.20714"},{"key":"bibr3-09564624221134137","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25162"},{"key":"bibr4-09564624221134137","volume-title":"National health commission of China: 104 500 000 people living with HIV in China","author":"China Central Television Network","year":"2020"},{"key":"bibr5-09564624221134137","doi-asserted-by":"publisher","DOI":"10.11816\/cn.ni.2020-192317"},{"key":"bibr6-09564624221134137","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.2095-5227.2021.01.010"},{"key":"bibr7-09564624221134137","doi-asserted-by":"publisher","DOI":"10.46234\/ccdcw2020.252"},{"key":"bibr8-09564624221134137","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31818ce6c4"},{"key":"bibr9-09564624221134137","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014181"},{"key":"bibr10-09564624221134137","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit246"},{"key":"bibr11-09564624221134137","volume-title":"European AIDS clinical society (EACS) guidelines","author":"European AIDS Clinical Society","year":"2021"},{"key":"bibr12-09564624221134137","volume-title":"Guidelines for the use of antiretroviral agents in adults and adolescents living with HIV","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents","year":"2021"},{"key":"bibr13-09564624221134137","volume-title":"Panel on opportunistic infections in adults and adolescents with HIV. 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