{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:43:52Z","timestamp":1777927432725,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>The prevalence of Paget\u2019s disease of bone (PDB) reaches 1\u20132% of all adults aged \u226555\u00a0years old. However, reports describing PDB among HIV positive patients are extremely rare. We report here the case of a HIV positive person receiving tenofovir disoproxil fumarate (DF)-based antiretroviral therapy and who had persistently elevated alkaline phosphatase (AP) revealing PDB. It is well established that tenofovir-DF use is associated with reversible increases in serum AP levels. Clinicians should bear in mind that persistently elevated AP in a person receiving tenofovir DF-based cART could be related to PDB, in particular in person older than 50 years with no other notable biological abnormalities related to kidney tubular dysfunction.<\/jats:p>","DOI":"10.1177\/09564624221136643","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T11:16:27Z","timestamp":1668424587000},"page":"137-138","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Persistently elevated alkaline phosphatase could be related to Paget\u2019s disease of bone in a patient receiving tenofovir disoproxil fumarate"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-4511","authenticated-orcid":false,"given":"Arthur","family":"Aubert","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, University Hospital of Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, University Hospital of Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambre","family":"Hittinger Roux","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital of Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"N\u2019Guyen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, University Hospital of Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-866X","authenticated-orcid":false,"given":"Firouz\u00e9","family":"Bani-Sadr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, University Hospital of Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"bibr1-09564624221136643","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-10-20-5690"},{"issue":"1","key":"bibr2-09564624221136643","first-page":"2","volume":"167","author":"Nebot Valenzuela E","year":"1946","journal-title":"Wien Med Wochenschr"},{"key":"bibr3-09564624221136643","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115224"},{"key":"bibr4-09564624221136643","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab232"},{"key":"bibr5-09564624221136643","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801300803"},{"issue":"2","key":"bibr6-09564624221136643","first-page":"59","volume":"18","author":"Casado JL","year":"2016","journal-title":"AIDS Rev Juin"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624221136643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624221136643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624221136643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:43:58Z","timestamp":1777675438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624221136643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1177\/09564624221136643"],"URL":"https:\/\/doi.org\/10.1177\/09564624221136643","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,14]]}}}