{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:43:38Z","timestamp":1777927418690,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2023,2]]},"abstract":"\n Aim<\/jats:title>\n \n To assess the prevalence of cryptococcal antigenemia among people living with HIV\/AIDS (PLHA) with CD4 \u2264100\/mm\n 3<\/jats:sup>\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n This observational study was performed on PLHA with laboratory-confirmed CD4 \u2264100\/mm\n 3<\/jats:sup>\n . All PLHA were recruited irrespective of their duration of HIV diagnosis, antiretroviral therapy (ART) na\u00efve, or ART failure.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The prevalence of cryptococcal antigen (CrAg) was assessed in 102 PLHA, with CD4 \u2264100\/mm\n 3<\/jats:sup>\n , using a latex agglutination test on serum samples. All the subjects were followed up for 3\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Amongst 102 PLHA, 62 (60.8%) and 40 (39.2%) patients were ART-na\u00efve and ART failures, respectively, with 2.9% ( n = 3) having clinical features of meningitis and 6.8% ( n = 7) patients being asymptomatic CrAg-positive. At the 3\u00a0month follow-up, total mortality was 10.8%, of which 33.3% and 8.8% were among CrAg-positive and negative patients ( p = 0.05). Mortality in asymptomatic and meningitis symptomatic CrAg-positive patients was 1.03% ( n = 1) and 2.06% ( n = 2), respectively. Of note, five patients were lost to follow-up.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Cryptococcal antigenemia is common among patients with CD4 \u2264100\/mm\n 3<\/jats:sup>\n who were either ART na\u00efve or had treatment failure. Asymptomatic patients who underwent pre-emptive therapy demonstrated good clinical outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/09564624221141157","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T06:09:54Z","timestamp":1669356594000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cryptococcal antigenemia in people living with HIV and AIDS"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-8735","authenticated-orcid":false,"given":"Jatin","family":"Ahuja","sequence":"first","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"},{"name":"Indraprastha Apollo Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Soneja","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveet","family":"Wig","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immaculata","family":"Xess","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Vibha","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Nischal","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"bibr1-09564624221141157","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.148372"},{"key":"bibr2-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1086\/507897"},{"key":"bibr3-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205030-00009"},{"key":"bibr4-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328322ffac"},{"key":"bibr5-09564624221141157","unstructured":"World Health Organization. Rapid advice: diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children, 2011."},{"key":"bibr6-09564624221141157","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.44823"},{"key":"bibr7-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30243-8"},{"key":"bibr8-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2010.02683.x"},{"key":"bibr9-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1086\/655143"},{"key":"bibr10-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1086\/597262"},{"key":"bibr11-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31811ed32c"},{"key":"bibr12-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.03.015"},{"key":"bibr13-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1143"},{"key":"bibr14-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-4-52"},{"issue":"4","key":"bibr15-09564624221141157","first-page":"14","volume":"65","author":"Anuradha S","year":"2017","journal-title":"J Assoc Physicians India"},{"key":"bibr16-09564624221141157","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy567"},{"key":"bibr17-09564624221141157","doi-asserted-by":"publisher","DOI":"10.4103\/ijmm.IJMM_15_596"},{"key":"bibr18-09564624221141157","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00409"}],"container-title":["International Journal of STD & AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624221141157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624221141157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624221141157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:44:02Z","timestamp":1777675442000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624221141157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1177\/09564624221141157"],"URL":"https:\/\/doi.org\/10.1177\/09564624221141157","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]}}}