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Herein we describe two cases of severe mpox in Chicago in the setting of advanced HIV and provide suggested guidance for managing cases of severe disease in immunocompromised patients based available data, CDC recommendations, and our experience managing these patients.<\/jats:p>","DOI":"10.1177\/09564624231152940","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T06:34:01Z","timestamp":1674887641000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment options for severe or refractory mpox virus infection in patients with advanced HIV"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-8039","authenticated-orcid":false,"given":"Natasha N","family":"Pettit","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Imam","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renslow","family":"Sherer","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddha","family":"Hazra","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"bibr1-09564624231152940","unstructured":"Centers for Disease Control and Prevention. Mpox outbreak, global map. Available at: https:\/\/www.cdc.gov\/poxvirus\/mpox\/response\/2022\/world-map.html. (2022, accessed 10 September 2022)."},{"issue":"44","key":"bibr2-09564624231152940","first-page":"1412","volume":"71","author":"Miller MJ","year":"2022","journal-title":"MMRW"},{"key":"bibr3-09564624231152940","unstructured":"Centers for Disease Control and Prevention. Severe manifestations of mpox among people who are immunocompromised due to hiv or other conditions. Health advisory, September 29, 2022. Available at: https:\/\/emergency.cdc.gov\/han\/2022\/han00475.asp (2022, accessed 29 September 2022)."},{"key":"bibr4-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00775-4"},{"key":"bibr5-09564624231152940","volume-title":"Clinical management and infection prevention and control for mpox: interim rapid response guidance, 10 June 2022","author":"Emergency Response, Guidelines Review Committee, and WHO Headquarters","year":"2022"},{"key":"bibr6-09564624231152940","unstructured":"European Centre for Disease Prevention and Control. Factsheet for health professionals on mpox. Last updated 25 October 2022. Available at: https:\/\/www.ecdc.europa.eu\/en\/all-topics-z\/mpox\/factsheet-health-professionals. (2022, accessed 20 November, 2022)."},{"key":"bibr7-09564624231152940","volume-title":"Clinical considerations for treatment and prophylaxis of mpox virus infection in people with HIV infection \u2013 United States, August 2022","author":"Centers for Disease Control and Prevention","year":"2022"},{"key":"bibr8-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00208-15"},{"key":"bibr9-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.15336"},{"key":"bibr10-09564624231152940","doi-asserted-by":"publisher","DOI":"10.7326\/L22-0300"},{"key":"bibr11-09564624231152940","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7137e1"},{"key":"bibr12-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28181"},{"key":"bibr13-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.11.001"},{"key":"bibr14-09564624231152940","unstructured":"University of Liverpool. HIV Drug Interactions. Available at: https:\/\/www.hiv-druginteractions.org\/drug_queries\/new (2022, Last updated 21 November 2022)."},{"key":"bibr15-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac310"},{"key":"bibr16-09564624231152940","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis510"},{"key":"bibr17-09564624231152940","unstructured":"Brincidofovir (Tembexa\u00ae) Prescribing information. Chimerix, Inc. Available at: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/214460s000,214461s000lbl.pdf (2022, accessed 1 November 2022)."},{"key":"bibr18-09564624231152940","unstructured":"Trifluridine \u2013 Drug Summary. 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Update on managing mpox in patients receiving therapeutics. Updated 4 November, 2022. Available at: https:\/\/emergency.cdc.gov\/han\/2022\/han00481.asp (2022, accessed 20 November 2022)."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624231152940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624231152940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624231152940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:44:20Z","timestamp":1777675460000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624231152940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,28]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/09564624231152940"],"URL":"https:\/\/doi.org\/10.1177\/09564624231152940","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,28]]}}}