{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:43:54Z","timestamp":1777927434086,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitors (ICIs) are effective strategies for multiple cancers and may be safe in people living with HIV (PLWH). Camrelizumab is a monoclonal antibody against PD-1 activating T cells against tumor cells. Evidence of camrelizumab\u2019s safety and activity in PLWH with urothelial carcinoma (UC) is lacking. Here, findings in a cohort of people living with HIV with advanced or metastatic urothelial carcinoma are presented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who had locally advanced or metastatic disease after radical surgery were given camrelizumab (200\u00a0mg intravenously every 3\u00a0weeks). The primary endpoint was objective response per Response Evaluation Criteria in Solid Tumors version 1.1. The second endpoint was adverse events after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, nine patients were included in this study with a median follow-up of 6.2\u00a0months (4.1\u201320.5). The objective response rate achieved 55%. Tumor response comprised 2 (22%) complete responses and 3 (33%) partial responses. The median of progression-free survival was 6.2\u00a0months (95% CI, 9.83\u201320.63). Only two grade 3 adverse reactions were reported (no toxic deaths or immune-related deaths).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Camrelizumab showed potent antitumor activity and acceptable safety in PLWH with advanced or metastatic urothelial carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624231173179","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T18:26:46Z","timestamp":1684780006000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Camrelizumab as adjuvant therapy in urothelial carcinomas after radical surgery in people living with HIV"],"prefix":"10.1177","volume":"34","author":[{"given":"Menghua","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology, Beijing Youan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefeng","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Urology, Yangquan Coal Industry Group Co Ltd General Hospital, Shanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Youan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5158-4363","authenticated-orcid":false,"given":"Jimao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 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