{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:43:55Z","timestamp":1777927435878,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Long-term use of antiretroviral therapy (ART) for HIV infection might lead to the necessity of switching regimens. We aimed to analyze the reasons for the ART switch, the time-to-switch of ART, and its associated factors in a Colombian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort in 20 HIV clinics, including participants \u226518\u00a0years old with confirmed HIV infection who underwent an ART switch from January 2017 to December 2019 with at least 6 months of follow-up. A time-to-event analysis and an exploratory Cox model were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>796 participants switched ART during the study period. The leading cause of ART switch was drug intolerance ( n = 449; 56.4%) with a median time-to-switch of 12.2\u00a0months. The longest median time-to-switch was due to regimen simplification (42.4\u00a0months). People \u226550\u00a0years old (HR = 0.6; 95% CI (0.5\u20130.7) and CDC stage 3 at diagnosis (HR = 0.8; 95% CI (0.6\u20130.9) had less hazard for switching ART over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this Colombian cohort, drug intolerance was the main cause of the ART switch, and the time-to-switch is shorter than reports from other countries. In Colombia, it is crucial to apply current recommendations for ART initiation to choose regimens with a better tolerability profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624231181156","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T17:32:31Z","timestamp":1689010351000},"page":"921-931","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Reasons for antiretroviral switching in Colombia: A retrospective cohort study"],"prefix":"10.1177","volume":"34","author":[{"given":"Sandra Liliana","family":"Valderrama-Beltr\u00e1n","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, School of Medicine. Research Group on Infectious Disease, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Grupo VIHCOL, Bogota, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Mart\u00ednez-Vernaza","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, School of Medicine. Research Group on Infectious Disease, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Grupo VIHCOL, Bogota, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-0098","authenticated-orcid":false,"given":"Shirley Vanessa","family":"Correa-Forero","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, School of Medicine. Research Group on Infectious Disease, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alejandra","family":"Jaimes-Reyes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, School of Medicine. Research Group on Infectious Disease, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Ar\u00e9valo-Mora","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Centro de Expertos para Atenci\u00f3n Integral. CEPAIN, Colombia, Bogota, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Mart\u00ednez-Buitrago","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Universidad Del Valle, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julieta","family":"Franco","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, SIES Salud, Pereira, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Beltr\u00e1n-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"MSD Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Urrego-Reyes","sequence":"additional","affiliation":[{"name":"MSD Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Leon","sequence":"additional","affiliation":[{"name":"MSD Colombia, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Garc\u00eda Garzon","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, SIES Salud, Pereira, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, SIES Salud, Pereira, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, Asistencia Cient\u00edfica de Alta Complejidad, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Botero","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"HIV Clinic, Todomed Cali, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Andrade","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"HIV Clinic, Infectocl\u00ednicos, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Alzamora","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, Vivir Bien Cartagena, Cartagena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Lenis","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, Recuperar IPS, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Pardo","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Centro de Expertos para Atenci\u00f3n Integral. CEPAIN, Colombia, Bogota, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Alzate-\u00c1ngel","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Department of HIV Clinic, CIB Medell\u00edn, Medell\u00edn, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Grupo VIHCOL, Bogota, Colombia"},{"name":"Centro de Expertos para Atenci\u00f3n Integral. 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