{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:46:45Z","timestamp":1792057605766,"version":"4.4.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People living with HIV (PLWH) starting or switching to an integrase strand transfer inhibitor-based regimen are more likely to experience weight gain than other classes of antiretroviral regimens. The aim of this study was to evaluate the weight gain and metabolic disturbances in PLWH who start antiretroviral therapy (ART) with bictegravir\/emtricitabine\/tenofovir alafenamide and in individuals who switch from another ART to BIC\/FTC\/TAF after 48\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective longitudinal study was conducted in an HIV clinic in Mexico. Weight and metabolic parameters were measured at baseline, 24 and 48\u00a0weeks. A paired t test and Wilcoxon signed-rank test were applied to evaluate weight and metabolic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      160 participants completed measurements, median age was 29 (IQR 26-32) and 30 (IQR 27\u201334)\u00a0years old for the treatment-na\u00efve and switch group respectively. In the treatment-na\u00efve group, mean weight change was 3.8\u00a0kg (\u00b15.8) ( p &lt; .001) and BMI increased 1.3\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\u00b12) ( p &lt; .001) at 48\u00a0weeks. Incidence of BMI &gt;25\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was 28% (95%CI; 18%\u201340%) and BMI &gt;30\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was 7% (95%CI; 2%\u201316%) at 48\u00a0weeks in treatment-na\u00efve individuals. In the switch group, mean weight gain and BMI change at 48\u00a0weeks was 2.8\u00a0kg (\u00b15.9) and 0.9\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (\u00b12.0) respectively ( p &lt; .001). Incidence of BMI &gt;25\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      was 17% (95%CI; 8%\u201332%) and BMI &gt;30\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      12.8% (95%CI; 5%\u201326%) at 48\u00a0weeks respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weight gain should be considered when men PLWH are treated with BIC\/FTC\/TAF regimen. They should be informed about this possible adverse event and strategies of intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624231196605","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T18:01:40Z","timestamp":1695232900000},"page":"33-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Weight gain and metabolic disturbances in people living with HIV who start antiretroviral therapy with, or switch to, bictegravir\/emtricitabine\/tenofovir alafenamide after 48 weeks of treatment: A real-world prospective study"],"prefix":"10.1177","volume":"35","author":[{"given":"Jos\u00e9 Antonio","family":"Mata Mar\u00edn","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Infectolog\u00eda \u201cLa Raza\u201d National Medical Center, Instituto Mexicano Del Seguro Social, Mexico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Velasco-Penagos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Infectolog\u00eda \u201cLa Raza\u201d National Medical Center, Instituto Mexicano Del Seguro Social, Mexico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mauss","sequence":"additional","affiliation":[{"name":"Center for HIV and Hepatogastroenterology, Duesseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8566-4003","authenticated-orcid":false,"given":"Mara Soraya","family":"Rodriguez-Evaristo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, General Hospital, \u201cLa Raza\u201d National Medical Center, Instituto Mexicano Del Seguro Social, Mexico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"P\u00e9rez-Barrag\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Infectolog\u00eda \u201cLa Raza\u201d National Medical Center, Instituto Mexicano Del Seguro Social, Mexico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Villa-Platas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Infectolog\u00eda \u201cLa Raza\u201d National Medical Center, Instituto Mexicano Del Seguro Social, Mexico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barrag\u00e1n-Huerta","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, M\u00e9xico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Enrique","family":"Gayt\u00e1n-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de Infectolog\u00eda \u201cLa Raza\u201d National Medical Center, Instituto Mexicano Del Seguro Social, Mexico city, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"bibr1-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz407"},{"key":"bibr2-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2020.1775074"},{"key":"bibr3-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1902824"},{"key":"bibr4-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001525"},{"key":"bibr5-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky145"},{"issue":"19","key":"bibr6-09564624231196605","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","journal-title":"JAMA"},{"key":"bibr7-09564624231196605","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57060578"},{"key":"bibr8-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2014-000174"},{"key":"bibr9-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904340"},{"key":"bibr10-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25702"},{"key":"bibr11-09564624231196605","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X20666220608160335"},{"key":"bibr12-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"bibr13-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1071\/SH23043"},{"key":"bibr14-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab621"},{"key":"bibr15-09564624231196605","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002350"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624231196605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624231196605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624231196605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:44:57Z","timestamp":1777675497000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624231196605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/09564624231196605"],"URL":"https:\/\/doi.org\/10.1177\/09564624231196605","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]}}}