{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:09Z","timestamp":1777927449354,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This case report describes the successful use of imiquimod to treat genital herpes in an immunocompetent individual with acyclovir-resistant HSV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 32\u00a0year old male patient, presented with asymptomatic non-healing ulcers over the genital region for 2\u00a0years. The ulcers initially responded to acyclovir but became persistent after a few months. He also received multiple courses of antibiotics. On examination, the patient had bilateral inguinal lymphadenopathy and multiple painless ulcers over the coronal sulcus. Routine investigations were normal. The patient was treated with oral and intravenous acyclovir but showed no response. He was then started on topical imiquimod cream applied on alternate days. After one week, the patient presented with pain, redness, burning sensation, and fresh ulcer over the glans which were suspected to be imiquimod-induced irritant reaction or ulcer. Imiquimod was withheld for one week and then restarted at a twice-weekly schedule. After 1\u00a0month and 7\u00a0days of treatment with imiquimod at a twice-weekly schedule, there was healing of the ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case report illustrates the efficacy of imiquimod cream as a topical treatment for genital herpes simplex in an immunocompetent patient who had previously been unresponsive to treatment with acyclovir.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624231213110","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:03:26Z","timestamp":1699434206000},"page":"231-233","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Recalcitrant ulcerative genital herpes in an immunocompetent individual treated successfully with imiquimod"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3576-512X","authenticated-orcid":false,"given":"Suvigya","family":"Sachan","sequence":"first","affiliation":[{"name":"Senior Resident, Department of Dermatology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay Kiran","family":"Potluri","sequence":"additional","affiliation":[{"name":"Non Academic Junior Resident, Department of Dermatology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hima","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Dermatology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kode Leela","family":"Sravanthi","sequence":"additional","affiliation":[{"name":"Senior Resident, Department of Dermatology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabhakaran","family":"N","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Dermatology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotsna Naresh","family":"Bharti","sequence":"additional","affiliation":[{"name":"Additional Professor and HOD, Department of Pathology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiruveedhula","family":"Haritha","sequence":"additional","affiliation":[{"name":"Additional Professor and HOD, Department of Dermatology, AIIMS Mangalagiri, Mangalagiri, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"bibr1-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.04.025"},{"key":"bibr2-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.06.037"},{"key":"bibr3-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.114-128.2003"},{"key":"bibr4-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.1.242-249.2004"},{"key":"bibr5-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1086\/514229"},{"key":"bibr6-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1159\/000246676"},{"key":"bibr7-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.02.002"},{"key":"bibr8-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.05.001"},{"key":"bibr9-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.10.3243-3248.2002"},{"key":"bibr10-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12479"},{"key":"bibr11-09564624231213110","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.047431"},{"key":"bibr12-09564624231213110","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0384"}],"container-title":["International Journal of STD &amp; 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