{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:11:06Z","timestamp":1791882666929,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Selection of an antiretroviral regimen for people living with HIV (PLWH) involves various clinical considerations, such as comorbidities, archived drug resistance mutations, concomitant medications, and potential drug interactions and side effects. Alterations in the surface area and pH of the gastrointestinal tract following bariatric surgery may alter absorption, antiretroviral pharmacokinetics and viral suppression. Data on the efficacy of antiretroviral (ARV) therapy in PLWH who have undergone bariatric surgery are limited or lacking for new antiretrovirals, such as dolutegravir and bictegravir.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case series reports virologic outcomes and side effects in eight cases of PLWH receiving ARV therapy who underwent bariatric surgery. A systematic literature review was performed to review the available literature on the efficacy and safety of antiretroviral regimens in PLWH who have undergone bariatric surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Virologic suppression was not impacted for obese PLWH who underwent bariatric surgery following failure of life-style modifications and pharmacological therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There were no deleterious effects on HIV progression for PLWH that underwent bariatric surgery. More prospective research is required to validate the effects of bariatric surgery on immunologic and virologic function outcomes. Close involvement of HIV and surgical specialists is recommended to manage ARV therapy in patients undergoing bariatric surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624231213114","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T04:03:31Z","timestamp":1699329811000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Virologic outcomes of antiretroviral therapy in patients with HIV-1 following bariatric surgery: A case series and review of the literature"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7564-0131","authenticated-orcid":false,"given":"Melissa","family":"Badowski","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Kassem","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Labedz","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Bunnell","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Hall","sequence":"additional","affiliation":[{"name":"Francisan Health -Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8361-852X","authenticated-orcid":false,"given":"Hannah","family":"Darnell","sequence":"additional","affiliation":[{"name":"Indiana University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Huesgen","sequence":"additional","affiliation":[{"name":"Indiana University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-020-00483-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.14.1724"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2015.09.002"},{"key":"e_1_3_3_5_2","volume-title":"Prevalence of overweight, obesity, and extreme obesity among adults aged 20 and over: United States, 1960\u20131962 through 2015\u20132016","author":"Centers for Disease Control and Prevention","unstructured":"Centers for Disease Control and Prevention. Prevalence of overweight, obesity, and extreme obesity among adults aged 20 and over: United States, 1960\u20131962 through 2015\u20132016. https:\/\/www.cdc.gov\/nchs\/data\/hestat\/obesity_adult_15_16\/obesity_adult_15_16.htm."},{"key":"e_1_3_3_6_2","unstructured":"American Society for Metabolic and Bariatric Surgery. 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Low third-trimester serum levels of lamivudine\/zidovudine and lopinavir\/ritonavir in an HIV-infected pregnant woman with gastric bypass. J Int Assoc Phys AIDS Care 2015; 14(2): 116\u2013199.","journal-title":"J Int Assoc Phys AIDS Care"},{"key":"e_1_3_3_13_2","volume-title":"Gastric bypass surgery and serum concentrations of zidovudine, lamivudine, and nelfinavir","author":"Razonable R","year":"2002","unstructured":"Razonable R, Estes L, Thompson G. Gastric bypass surgery and serum concentrations of zidovudine, lamivudine, and nelfinavir. 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