{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:57:33Z","timestamp":1789088253465,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI09972"],"award-info":[{"award-number":["R01AI09972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sexually transmitted infections (STIs) associated with genital ulcer disease due to herpes simplex virus-2 (HSV-2) are a prominent cause of morbidity and mortality. Serologic screening for HSV-2 is recommended only for individuals with genital herpes symptom history. However, no validated symptom screening tool currently exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Currently asymptomatic adults presenting for routine care at STI clinics in Lima, Peru completed a survey of prior genital herpes symptoms and received HSV-2 serological testing with the Euroimmun Anti-HSV-2 (gG2) ELISA IgG (Lubeck, Germany). A sub-sample of indeterminate results were sent for Western blot confirmatory testing. We assessed associations between past symptoms and anti-HSV-2 positivity and corrected the HSV-2 prevalence by re-classifying indeterminates per Western Blot results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We enrolled 131 participants between July and October 2022. HSV-2 antibody test results found 21.4% positive, 41.2% indeterminate, and 37.4% negative. Excluding indeterminate results, 36.4% were positive. Of participants with no prior symptoms 31.2% tested positive, compared to 35.7% with one prior symptom, 50.0% with 2, and 50.0% with 3+ prior symptoms. Among the sub-sample of indeterminates, 92.6% were confirmed positive by Western Blot, bringing the total estimated proportion of participants with HSV-2 antibodies to 59.5%. Either based on the original classification of HSV-2 antibody status or after incorporation of confirmatory testing results, there was no significant association between symptom history and HSV-2 antibody positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With currently available tests, recommendations to screen individuals based on genital herpes symptom history may not be useful. More discriminatory symptom screening tools or HSV-2 antibody tests with better performance are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624231213116","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T04:01:20Z","timestamp":1699416080000},"page":"169-175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Does genital herpes symptom history predict herpes simplex virus type 2 antibody positivity?"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-5133","authenticated-orcid":false,"given":"Jessica","family":"Perez","sequence":"first","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silver","family":"Vargas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Interdisciplinaria en Sexualidad, SIDA y Sociedad, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6922-7364","authenticated-orcid":false,"given":"Jeffrey D","family":"Klausner","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelika A","family":"Konda","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"bibr1-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000694"},{"key":"bibr2-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114989"},{"key":"bibr3-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1136\/sti.79.4.280"},{"key":"bibr4-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30405-X"},{"key":"bibr5-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0807633"},{"key":"bibr6-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-014-0358-x"},{"key":"bibr7-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0057"},{"key":"bibr8-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24870"},{"key":"bibr9-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.17138"},{"key":"bibr10-09564624231213116","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7004a1"},{"key":"bibr11-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab1056"},{"key":"bibr12-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1086\/426438"},{"key":"bibr13-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000175413.89733.ae"},{"key":"bibr14-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1086\/342104"},{"key":"bibr15-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91496-X"},{"key":"bibr16-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.4.3.228"},{"key":"bibr17-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2004.011957"},{"key":"bibr18-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(99)90016-4"},{"issue":"12","key":"bibr19-09564624231213116","first-page":"428","volume":"12","author":"Kropp Kai A","year":"2020","journal-title":"Viruses"},{"key":"bibr20-09564624231213116","doi-asserted-by":"publisher","DOI":"10.15698\/mic2016.09.528"},{"key":"bibr21-09564624231213116","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01701-19"}],"container-title":["International Journal of STD &amp; 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