{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:23Z","timestamp":1777927463691,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to elucidate the demographic characteristics, clinical features, diagnostic approaches, and medical management of patients with ocular syphilis, known as \u2018the great masquerader,\u2019 at a tertiary eye care center in Nepal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review involving 15 eyes from ten patients with ocular syphilis treated at a uveitis referral center between 2020 and 2022. Lumbar puncture was performed if neurosyphilis was suspected. Treatment success was defined as the absence of ocular inflammation in both eyes and a decrease in Veneral disease research laboratory (VDRL) titres after completing therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 15 eyes of 10 patients were diagnosed with syphilitic uveitis based on positive treponemal and non-treponemal serological tests. The mean age of the patient was 39.9\u00a0years (range 22-54\u00a0years) with an equal distribution between males and females. HIV coinfection was not found in any of the patients. Syphilitic uveitis was the primary presentation in nine patients (90%), while one patient presented with recurrent nodular scleritis. Ocular involvement was bilateral in 50% (5 patients). The mean duration between the initial symptom and the first presentation was 8.7\u00a0weeks (range: 4\u00a0days to 24\u00a0weeks). The most common ocular findings was panuveitis (6 eyes). Eight patients with early syphilis received weekly intramuscular injections of benzathine penicillin G for 3 weeks whereas 2 patients with neurosyphilis were treated with intravenous ceftriaxone 1 gm twice a day for 14 days. Signs and symptoms of majority of patients improved with systemic therapy for syphilis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Syphilitic uveitis should be included in the differential diagnosis of any form of ocular inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241232451","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T08:37:45Z","timestamp":1709282265000},"page":"527-534","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights into ocular syphilis in Nepal"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-6938","authenticated-orcid":false,"given":"Sadhana","family":"Sharma","sequence":"first","affiliation":[{"name":"B.P. Koirala Lions Center for Ophthalmic Studies (BPKLCOS), Institute of Medicine, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranju","family":"Kharel","sequence":"additional","affiliation":[{"name":"B.P. Koirala Lions Center for Ophthalmic Studies (BPKLCOS), Institute of Medicine, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanket","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Reiyukai Eiko Masunaga Eye Hospital, Banepa, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchi","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Reiyukai Eiko Masunaga Eye Hospital, Banepa, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shradha","family":"Tiwari","sequence":"additional","affiliation":[{"name":"B.P. Koirala Lions Center for Ophthalmic Studies (BPKLCOS), Institute of Medicine, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himang","family":"Singh Maskey","sequence":"additional","affiliation":[{"name":"B.P. Koirala Lions Center for Ophthalmic Studies (BPKLCOS), Institute of Medicine, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"issue":"1","key":"bibr1-09564624241232451","first-page":"4","volume":"7","author":"Tampa M","year":"2014","journal-title":"Journal of medicine and life"},{"key":"bibr2-09564624241232451","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14559"},{"key":"bibr3-09564624241232451","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05122-3"},{"key":"bibr4-09564624241232451","volume-title":"Syphilis ocular manifestations","author":"Koundanya VV","year":"2020"},{"key":"bibr5-09564624241232451","doi-asserted-by":"publisher","DOI":"10.2147\/IMCRJ.S111349"},{"key":"bibr6-09564624241232451","doi-asserted-by":"publisher","DOI":"10.3201\/eid2402.171167"},{"key":"bibr7-09564624241232451","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7004a1"},{"key":"bibr8-09564624241232451","first-page":"509","volume":"1403","author":"Group SoUNW","year":"2005","journal-title":"Journal of Ophthalmology"},{"key":"bibr9-09564624241232451","first-page":"2","volume":"5","author":"Kharel R","year":"2019","journal-title":"New Front Ophthalmol"},{"key":"bibr10-09564624241232451","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.155"},{"key":"bibr11-09564624241232451","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17906"},{"key":"bibr12-09564624241232451","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.10.030"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241232451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241232451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241232451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:45:25Z","timestamp":1777675525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241232451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/09564624241232451"],"URL":"https:\/\/doi.org\/10.1177\/09564624241232451","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}