{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:47Z","timestamp":1777927487810,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"PReventing the Emergence of untreatable STIs via radical Prevention","award":["SOFI 2021"],"award-info":[{"award-number":["SOFI 2021"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Tetracycline and macrolide resistance are frequently linked in streptococci and other species. We aimed to assess the association between doxycycline use and azithromycin MICs in oral streptococci.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Linear regression was used to assess the association between doxycycline use in the prior year and the median MIC per participant of oral streptococcal colonies isolated at the baseline visit of the ResistAZM study. The analysis controlled for receipt of other antimicrobials as well as time since antimicrobial consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-six individual colonies confirmed to be streptococci were isolated from 19 individuals at baseline. The azithromycin MICs of these isolates varied considerably between 0.25\u00a0mg\/L and &gt;256\u00a0mg\/L (median 28\u00a0mg\/L; IQR 1-192\u00a0mg\/L). The consumption of doxycycline in the preceding 12 months was positively associated with median streptococcal azithromycin MIC (coef. 151.6 [95% CI 10.6-292.7]; p = .037).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This post-hoc analysis found that doxycycline use was associated with streptococcal azithromycin susceptibility. Numerous limitations of the study design mean that this study is best considered hypothesis generating. Prospective studies are required to assess if the use of doxycycline could select for macrolide resistance in oral streptococci.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241246301","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T11:11:30Z","timestamp":1712920290000},"page":"658-661","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral streptococcal susceptibility to azithromycin may be associated with doxycycline use: A post-hoc analysis with implications for doxycycline post exposure prophylaxis"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-6041","authenticated-orcid":false,"given":"Thibaut","family":"Vanbaelen","sequence":"first","affiliation":[{"name":"STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-252X","authenticated-orcid":false,"given":"Irith","family":"De Baetselier","sequence":"additional","affiliation":[{"name":"Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheeba Santhini","family":"Manoharan-Basil","sequence":"additional","affiliation":[{"name":"STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-8998","authenticated-orcid":false,"given":"Chris","family":"Kenyon","sequence":"additional","affiliation":[{"name":"STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"},{"name":"Division of Infectious Diseases and HIV Medicine, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"bibr1-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30725-9"},{"key":"bibr2-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211934"},{"key":"bibr3-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad553"},{"key":"bibr4-09564624241246301","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1983.15.issue-3.10"},{"key":"bibr5-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1177\/09564624231190108"},{"key":"bibr6-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.02.017"},{"key":"bibr7-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1128\/mr.59.4.579-590.1995"},{"key":"bibr8-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2004.10.231"},{"key":"bibr9-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad462"},{"key":"bibr10-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197905103001903"},{"key":"bibr11-09564624241246301","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00688-16"},{"key":"bibr12-09564624241246301","volume-title":"Current Research in Microbial Sciences","author":"Kenyon C","year":"2023"},{"issue":"9","key":"bibr13-09564624241246301","first-page":"000622","volume":"7","author":"Kalizang'oma A","year":"2021","journal-title":"Microb Genom"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241246301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241246301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241246301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:45:34Z","timestamp":1777675534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241246301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/09564624241246301"],"URL":"https:\/\/doi.org\/10.1177\/09564624241246301","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}