{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:45:26Z","timestamp":1777927526730,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Merck Sharp & Dohme, LDA, Portugal","award":["Protocol NIS008356"],"award-info":[{"award-number":["Protocol NIS008356"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a lack of up-to-date real-life evidence on antiretroviral therapy (ART) strategies among people living with HIV (PLWH) in Portugal. This study aimed to describe the treatment strategy used in PLWH either initiating or switching ART.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Non-interventional, cross-sectional, multicenter study carried out between December 2019 and October 2021 in Portugal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 237 PLWH were included in this study, 171 of whom were ART-experienced and 66 were ART-na\u00efve. The study showed that triple regimens were the most common ART strategy and integrase strand transfer inhibitors-based therapy was the most frequently used therapeutic class in both ART-na\u00efve and ART-experienced PLWH. Nevertheless, about a third of PLWH who started a triple regimen transitioned to a dual regimen. Patient-reported outcomes revealed high HIV literacy and similar ART preferences in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This real-world study showed that triple regimens were the most widely used ART strategy, even after the European AIDS Clinical Society guidelines introduced the recommendation of a dual regimen for na\u00efve patients. The cohorts of this study presented a high level of HIV literacy at the time of inclusion. Our findings highlighted that taking pills only once a day is considered a very important feature for most patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241263122","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T12:46:11Z","timestamp":1721911571000},"page":"873-883","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment patterns and preferences of people living with HIV starting or switching antiretroviral therapy: Real-world evidence from Portugal"],"prefix":"10.1177","volume":"35","author":[{"given":"Liliana","family":"Pedro","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital de Portim\u00e3o, Centro Hospitalar Universit\u00e1rio Do Algarve, Portim\u00e3o, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Zagalo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Santa Maria, Centro Hospitalar Universit\u00e1rio Lisboa Norte, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Hospital Beatriz \u00c2ngelo, Loures, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Hospital Prof. Dr Fernando da Fonseca, Amadora, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Vaz Pinto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital de Cascais, Cascais, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1rio","family":"Serr\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital de S\u00e3o Jo\u00e3o, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Hospital de Vila Real, Centro Hospitalar Tr\u00e1s-os-Montes e Alto Douro, Vila Real, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Hospital Garcia de Orta, Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Maltez","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Hospital Curry Cabral, Centro Hospitalar Universit\u00e1rio Lisboa Central, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Infectiology, Hospital Pedro Hispano, Unidade Local de Sa\u00fade de Matosinhos, Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5683-3181","authenticated-orcid":false,"given":"Alexandre","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital de Braga, Braga, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eug\u00e9nio","family":"Te\u00f3filo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital dos Capuchos, Centro Hospitalar Universit\u00e1rio Lisboa Central, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Almeida","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, MSD Portugal, Pa\u00e7o de Arcos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0003-4636","authenticated-orcid":false,"given":"In\u00eas","family":"Lains","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, MSD Portugal, Pa\u00e7o de Arcos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"bibr1-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-3018(17)30086-3"},{"key":"bibr2-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1097\/coh.0000000000000298"},{"key":"bibr3-09564624241263122","volume-title":"Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach","author":"WHO","year":"2021"},{"key":"bibr4-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2018.02.010"},{"key":"bibr5-09564624241263122","volume-title":"EACS guidelines","author":"EACS","year":"2021"},{"key":"bibr6-09564624241263122","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.926565"},{"key":"bibr7-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.03.004"},{"key":"bibr8-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00750.x"},{"key":"bibr9-09564624241263122","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S22771"},{"key":"bibr10-09564624241263122","first-page":"93","volume":"27","author":"Pedrol E","year":"2014","journal-title":"Rev Esp Quimioter"},{"key":"bibr11-09564624241263122","unstructured":"VIH\/SID PNpaI. Recomenda\u00e7\u00f5es Portuguesas para o tratamento da infe\u00e7\u00e3o por VIH-1 e VIH- 2 \u2013 2016. VIH\/SIDA PNpaI, 2016."},{"key":"bibr12-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2011.630362"},{"key":"bibr13-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-010-9863-0"},{"key":"bibr14-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1177\/2325958219867325"},{"key":"bibr15-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148231"},{"key":"bibr16-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12695"},{"key":"bibr17-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12878"},{"key":"bibr18-09564624241263122","volume-title":"HIV\/AIDS surveillance in Europe 2023 \u2013 2022 data","author":"Europe ECDPCWRO","year":"2023"},{"key":"bibr19-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)60821-6"},{"key":"bibr20-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2019.1634786"},{"key":"bibr21-09564624241263122","unstructured":"SER+ and GNP+. Avalia\u00e7\u00e3o do \u00cdndice de Estigma das PVV em Portugal Lisboa2014."},{"key":"bibr22-09564624241263122","unstructured":"Esteves A. Portugal: 2021 census confirms growth in immigrant population, https:\/\/ec.europa.eu\/migrant-integration\/news\/portugal-2021-census-confirms-growth-immigrant-population_en (2021)."},{"key":"bibr23-09564624241263122","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254-6450.2018.04.020"},{"key":"bibr24-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1177\/0049475520908180"},{"key":"bibr25-09564624241263122","doi-asserted-by":"publisher","DOI":"10.2174\/1871525713666150310112350"},{"key":"bibr26-09564624241263122","volume-title":"Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV","author":"WHO","year":"2015"},{"key":"bibr27-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-534"},{"key":"bibr28-09564624241263122","doi-asserted-by":"publisher","DOI":"10.18332\/popmed\/156768"},{"key":"bibr29-09564624241263122","doi-asserted-by":"publisher","DOI":"10.35772\/ghm.2021.01103"},{"key":"bibr30-09564624241263122","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7125a2"},{"key":"bibr31-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06490-0"},{"key":"bibr32-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256330"},{"key":"bibr33-09564624241263122","unstructured":"Jorge INdSDR. Infe\u00e7\u00e3o por VIH em Portugal - 2022, https:\/\/www.backoffice.dgs.pt\/upload\/DGSv9\/ficheiros\/i029981.pdf."},{"key":"bibr34-09564624241263122","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-022-03854-8"},{"key":"bibr35-09564624241263122","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182312765"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241263122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241263122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241263122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:45:46Z","timestamp":1777675546000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241263122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/09564624241263122"],"URL":"https:\/\/doi.org\/10.1177\/09564624241263122","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]}}}