{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:44:28Z","timestamp":1778035468940,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["NIH R21MH118110"],"award-info":[{"award-number":["NIH R21MH118110"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transgender women are a key population in the HIV epidemic globally, including in Peru. This cross-sectional epidemiological study characterized the pre-exposure prophylaxis (PrEP) cascade in adolescent and young adult transgender women in Peru to inform roll-out of early HIV prevention efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between February-July 2022, a community-recruited sample of HIV-negative or status unknown young transgender women ( n = 140) in Peru completed a socio-behavioral survey and biological testing for HIV and bacterial STIs. Logistic regression models estimated the association of sociodemographic, healthcare, and behavioral factors to PrEP indication and willingness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age was 22\u00a0years (range = 16-24 years); 65.7% reported sex work and 28.6% homelessness. Overall, 45.7% had a PrEP indication based on past 6\u00a0months HIV behavioral risk profiles. In a multivariable model, sex work (aRR = 2.27; 95% CI = 1.24-4.17) and homelessness (aRR = 1.27; 95% CI = 1.00-1.60) were associated with PrEP indication. More than one-third (38.6%) had never been HIV tested; 25.3% were tested &gt;1 year ago. Only 34.3% heard of daily oral PrEP, 8.6% reported ever PrEP use, and 5.0% current PrEP use. Nearly half (49.3%) reported willingness to take daily oral PrEP. In a multivariable model, younger age was associated with increased willingness to use PrEP (aRR = 0.92; 95% CI = 0.87-0.98). Highest ranked PrEP preferences were a daily oral pill (35.7%), implant (32.1%), and injection by a provider (10.0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PrEP indication and willingness were high in this sample, but HIV testing and PrEP uptake were low. Findings highlight opportunities for age-responsive and contextually-relevant interventions to increase HIV prevention among young transgender women in Peru.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241272940","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T01:48:07Z","timestamp":1731894487000},"page":"141-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The PrEP cascade in a sample of HIV-negative or unknown status adolescent and young adult transgender women in Peru"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-4746","authenticated-orcid":false,"given":"Sari L","family":"Reisner","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA"},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Apedaile","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Silva-Santisteban","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research in Sexuality, AIDS and Society, University of Peru Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"Huerta","sequence":"additional","affiliation":[{"name":"Feminas, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Aguayo-Romero","sequence":"additional","affiliation":[{"name":"The Whitman Walker Institute, Whitman Walker Health, Washington DC, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaya","family":"Perez-Brumer","sequence":"additional","affiliation":[{"name":"Division of Social and Behavioural Sciences, Dalla Lana School of Public Health, University of Toronto, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"bibr1-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260063"},{"key":"bibr2-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-011-0053-5"},{"key":"bibr3-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-023-04043-x"},{"key":"bibr4-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001087"},{"key":"bibr5-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1080\/17441692.2020.1856397"},{"key":"bibr6-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1186\/s41256-023-00317-y"},{"key":"bibr7-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-021-03445-z"},{"key":"bibr8-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-017-1768-8"},{"key":"bibr9-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1089\/lgbt.2022.0054"},{"key":"bibr10-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25769"},{"key":"bibr11-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25974"},{"key":"bibr12-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1089\/lgbt.2018.0087"},{"key":"bibr13-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00206-4"},{"key":"bibr14-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"bibr15-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00071-0"},{"key":"bibr16-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101016"},{"key":"bibr17-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1177\/20499361231164030"},{"key":"bibr18-09564624241272940","unstructured":"Peru Ministry of Health. Norma Tecnica de Salud \u201cPrevencion Combinada del Virus de La Inmunodeficiencia Humana Para Poblaciones en alto Riesgo; 2023."},{"key":"bibr19-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00331-9"},{"key":"bibr20-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy030"},{"key":"bibr21-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1037\/cpp0000297"},{"key":"bibr22-09564624241272940","unstructured":"Centers for Disease Control and Prevention (CDC). US public health service: preexposure prophylaxis for the prevention of HIV infection in the United States-2021 update: a clinical practice guideline, https:\/\/www.cdc.gov\/hiv\/pdf\/risk\/prep\/cdc-hiv-prep-guidelines-2021.pdf (2021)."},{"key":"bibr23-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"bibr24-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30236-6"},{"key":"bibr25-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2022.0043"},{"key":"bibr26-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2022.0044"},{"key":"bibr27-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25786"},{"key":"bibr28-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1177\/23259582231196705"},{"key":"bibr29-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-020-03117-4"},{"key":"bibr30-09564624241272940","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2019.1634787"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241272940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241272940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241272940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:45:50Z","timestamp":1777675550000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241272940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,17]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/09564624241272940"],"URL":"https:\/\/doi.org\/10.1177\/09564624241272940","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,17]]}}}