{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:45:08Z","timestamp":1777927508340,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are still many patients newly diagnosed with HIV at an advanced stage in Indonesia. We aimed to identify factors associated with 1-year mortality among cytomegalovirus (CMV)-infected people living with HIV (PLHIV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was carried out at a tertiary-care hospital in Jakarta, Indonesia (January 2017 to December 2022). We included PLHIV with CMV end-organ disease (EOD) and CMV syndrome. The presence of CMV infection was confirmed by fulfilling one of the following criteria: (1) positive PCR from plasma, urine, cerebrospinal fluid, or other body fluids, or associated tissue for CMV EOD; (2) positive immunoglobulin M (IgM); or (3) consistent symptoms and signs of CMV retinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 1737 PLHIV, 147 (8.5%, 95% CI: 7.2 to 9.9%) were diagnosed with CMV infection. Forty (27.2%, 95% CI: 20.6 to 35.1%) patients died within 1\u00a0year of being diagnosed. Only anti-retroviral therapy (ART) defaulting (aHR 3.31, 95% CI: 1.12 to 9.73) was found to be significantly associated with 1-year mortality in multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Defaulted ART status is significantly associated with reduced 1-year survival after CMV infection diagnosis. Patients with low CD4 counts, especially those with &lt;50 cells\/\u03bcL, should be assessed for CMV infection, monitored, and treated accordingly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241273848","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T19:03:15Z","timestamp":1724266995000},"page":"982-989","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality of cytomegalovirus infection among people living with HIV: A retrospective study from a tertiary hospital in Indonesia"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-0559","authenticated-orcid":false,"given":"Evy","family":"Yunihastuti","sequence":"first","affiliation":[{"name":"Cipto Mangunkusumo Hospital"},{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nia","family":"Kurniati","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"},{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-1825","authenticated-orcid":false,"given":"Muhammad","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi","family":"Yasmon","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fithriyah","family":"Sjatha","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukman","family":"Edwar","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia Aziza","family":"Nusyirwan","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darma","family":"Imran","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juferdy","family":"Kurniawan","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Mira","family":"Lubis","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Yulianti","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceva Wicaksono","family":"Pitoyo","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pringgodigdo","family":"Nugroho","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusiani","family":"Rusdi","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adityo","family":"Susilo","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sinto","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Muktiarti","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartika","family":"Maharani","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia Irsha","family":"Adhari","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7026-5341","authenticated-orcid":false,"given":"Rina La Distia","family":"Nora","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yustika Novianti","family":"Achmad","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Molan","family":"Purap","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teguh Harjono","family":"Karjadi","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"},{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvina","family":"Widhani","sequence":"additional","affiliation":[{"name":"Cipto Mangunkusumo Hospital"},{"name":"Cipto Mangunkusumo Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835b0fa2"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266438"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.876430"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002523"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.141636"},{"key":"e_1_3_5_7_2","volume-title":"Harrison\u2019s principles of internal medicine","author":"Fauci AS","year":"2018","unstructured":"Fauci AS, Folkers GK, Lane HC. Human immunodeficiency virus disease: AIDS and related disorders. In: Jameson JL, Kasper DL, Longo DL, et al. (eds). Harrison\u2019s principles of internal medicine. 20th ed. New York, NY: McGraw-Hill Education, 2018.","edition":"20"},{"key":"e_1_3_5_8_2","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3389\/fmicb.2015.01016","article-title":"Ongoing burden of disease and mortality from HIV\/CMV coinfection in Africa in the antiretroviral therapy era","volume":"6","author":"Adland E","year":"2015","unstructured":"Adland E, Klenerman P, Goulder P, et al. Ongoing burden of disease and mortality from HIV\/CMV coinfection in Africa in the antiretroviral therapy era. Front Microbiol 2015; 6(SEP): 1016.","journal-title":"Front Microbiol"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit494"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01322-8"},{"issue":"1","key":"e_1_3_5_12_2","first-page":"62","article-title":"Ocular diseases among HIV\/AIDS patients in Jakarta, Indonesia","volume":"44","author":"Lestari YD","year":"2013","unstructured":"Lestari YD, Sitompul R, Edwar L, et al. Ocular diseases among HIV\/AIDS patients in Jakarta, Indonesia. Southeast Asian J Trop Med Publ Health 2013; 44(1): 62\u201371.","journal-title":"Southeast Asian J Trop Med Publ Health"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.149880"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ215"},{"key":"e_1_3_5_15_2","volume-title":"Indonesian national guideline for medical Services in HIV management","author":"Indonesian Ministry of Health","year":"2019","unstructured":"Indonesian Ministry of Health. Indonesian national guideline for medical Services in HIV management. Jakarta: Indonesian Ministry of Health, 2019. Available from: https:\/\/siha.kemkes.go.id\/portal\/files_upload\/PNPK_HIV_Kop_Garuda__1_.pdf"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-1352"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002483"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4643-6"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000241"},{"issue":"9","key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/QAD.0000000000003238","article-title":"Cytomegalovirus viremia and risk of disease progression and death in HIV-positive patients starting antiretroviral therapy","volume":"36","author":"Levi LI","year":"2022","unstructured":"Levi LI, Sharma S, Schleiss MR, et al. Cytomegalovirus viremia and risk of disease progression and death in HIV-positive patients starting antiretroviral therapy. AIDS 2022; 36(9): 1265\u20131272.","journal-title":"AIDS"},{"key":"e_1_3_5_21_2","volume-title":"HIV-1\u2013associated opportunistic infections","author":"Vaillant AAJ","year":"2023","unstructured":"Vaillant AAJ, Naik R. HIV-1\u2013associated opportunistic infections. St. Petersburg, FL: StatPearls, 2023. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539787\/."},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.157166"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001144"},{"issue":"9","key":"e_1_3_5_24_2","first-page":"1396","article-title":"Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy in patients with acquired immunodeficiency syndrome","volume":"10","author":"Chen C","year":"2017","unstructured":"Chen C, Guo CG, Meng L, et al. Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy in patients with acquired immunodeficiency syndrome. Int J Ophthalmol 2017; 10(9): 1396\u20131401. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/28944199\/","journal-title":"Int J Ophthalmol"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8010055"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10349"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169651"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2020.08.012"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8659372"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001293"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-021-00822-7"},{"key":"e_1_3_5_32_2","first-page":"232595821989953","article-title":"Factors affecting virological outcome when first-line antiretroviral therapy is reintroduced after unplanned interruption","volume":"19","author":"Maria S","year":"2020","unstructured":"Maria S, Yunihastuti E, Saldi SRF, et al. Factors affecting virological outcome when first-line antiretroviral therapy is reintroduced after unplanned interruption. J Int Assoc Phys AIDS Care 2020; 19. 2325958219899534.","journal-title":"J Int Assoc Phys AIDS Care"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63177-7"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu291"},{"key":"e_1_3_5_35_2","first-page":"1","article-title":"AIDS cholangiopathy secondary to cytomegalovirus as possible unmasking immune reconstitution inflammatory syndrome in human immunodeficiency virus-infected individual: case report and review of the literature","volume":"2018","author":"Topiwala M","year":"2018","unstructured":"Topiwala M, Dubale N, Medisetty MK, et al. AIDS cholangiopathy secondary to cytomegalovirus as possible unmasking immune reconstitution inflammatory syndrome in human immunodeficiency virus-infected individual: case report and review of the literature. Case Rep Infect Dis 2018; 2018: 1\u20134.","journal-title":"Case Rep Infect Dis"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018163"},{"issue":"10","key":"e_1_3_5_37_2","first-page":"730","article-title":"Cytomegalovirus retinitis after initiation of antiretroviral therapy","volume":"51","author":"Ahmadinejad Z","year":"2013","unstructured":"Ahmadinejad Z, Ghetmiri Z, Rasoolinejad M. Cytomegalovirus retinitis after initiation of antiretroviral therapy. Acta Med Iran 2013; 51(10): 730\u2013732. Available from: https:\/\/acta.tums.ac.ir\/index.php\/acta\/article\/view\/4372","journal-title":"Acta Med Iran"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241273848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241273848","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241273848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:45:55Z","timestamp":1777675555000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241273848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,20]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/09564624241273848"],"URL":"https:\/\/doi.org\/10.1177\/09564624241273848","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,20]]}}}