{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:01:26Z","timestamp":1787839286915,"version":"build-2784847793"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","award":["D43CA153715"],"award-info":[{"award-number":["D43CA153715"]}],"id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HPV-related vulvar cancer is increasing in prevalence, especially in women living with HIV. Treatment of vulva cancer is based on evidence from HPV-independent cancers, which affect older women. The impact of HIV on vulvar cancer characteristics and treatment outcomes needs to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>A retrospective observational study compared the clinical characteristics, treatment, and outcomes of 92 HIV-positive and 131 HIV-negative women with vulvar cancer at our institution. Using descriptive statistics, HIV-positive and negative patients were compared and Cox regression models were tested for differences in mortality and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HIV-positive patients were 20 years younger than HIV-negative patients ( p &lt; 0.001). More than 50% of patients presented with advanced stage cancer, however this was independent of HIV-status. Although HIV infection was associated with poorer survival ( p = 0.022); rates of cure ( p = 0.933) and recurrence rates ( p = 0.8) were similar in HIV-positive and negative women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vulvar cancer occurs at a much younger age in women living with HIV. Awareness among HIV-positive women and health care providers would lead to diagnosis of vulvar cancer at an earlier stage. Treatment protocols for HPV-related vulvar cancer should not be altered due to HIV status and should take into consideration the young age of the patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241287260","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T14:16:04Z","timestamp":1727964964000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of concurrent HIV-infection on women with vulvar cancer: Comparison of clinical characteristics and outcome"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-1245","authenticated-orcid":false,"given":"Jennifer L","family":"Butt","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Tygerberg Hospital, Stellenbosch University, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M","family":"Simonds","sequence":"additional","affiliation":[{"name":"Department of Oncology, Tygerberg Hospital, Stellenbosch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthys H","family":"Botha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Tygerberg Hospital, Stellenbosch University, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"bibr1-09564624241287260","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182472947"},{"key":"bibr2-09564624241287260","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00045-S"},{"key":"bibr3-09564624241287260","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6466"},{"key":"bibr4-09564624241287260","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000253361.63578.14"},{"key":"bibr5-09564624241287260","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181743327"},{"key":"bibr6-09564624241287260","unstructured":"Maluleke R. 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