{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:08:12Z","timestamp":1789168092249,"version":"build-2803163510"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Long-acting (LA) cabotegravir\/rilpivirine (CAB\/RPV) is primarily prescribed for virologically suppressed persons living with HIV (PLWH). Patients experiencing pill dysphagia or profound adherence challenges were excluded from the phase 3 studies, but recent reports demonstrate successful treatment in PWLH with baseline viremia. We describe two PLWH with detectable viral loads (VL) with multidrug resistance mutations. They were unable to sustain virologic suppression on oral therapy with historical poor adherence and dysphagia. Initiation of intramuscular CAB\/RPV with subcutaneous lenacapavir (LEN) injections was necessary with baseline resistance. Due to anorexia and a low muscle mass, one patient received CAB\/RPV injections in the vastus lateralis rather than the gluteal muscle with a 67-day delay between injections three and four due to health challenges. Both achieved viral suppression on monthly CAB\/RPV with LEN. A return to health with a BMI increase from &lt;14\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    to almost 17\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    resulted in the second patient. Injectable LA ART (CAB\/RPV + LEN) in PLWH with detectable viremia results in sustained virologic suppression and a return to health and should now be considered a novel option for MDR patients with an inability to adhere to oral regimens.\n                  <\/jats:p>","DOI":"10.1177\/09564624241288293","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T14:28:22Z","timestamp":1727965702000},"page":"155-157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case series of two persons living with HIV with detectable viral loads initiated then suppressed on cabotegravir\/rilpivirine with lenacapavir"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1482-0206","authenticated-orcid":false,"given":"Kimberly L.","family":"O\u2019Neil","sequence":"first","affiliation":[{"name":"Virginia Commonwealth University Health, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-2799","authenticated-orcid":false,"given":"Patrick R.","family":"Ching","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Health, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Higginson","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Health, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-7205","authenticated-orcid":false,"given":"Patricia","family":"Pecora Fulco","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Health, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"bibr1-09564624241288293","volume-title":"Guidelines for the use of antiretroviral agents in adults and adolescents with HIV","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents","year":"2024"},{"key":"bibr2-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.22246"},{"key":"bibr3-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae125"},{"key":"bibr4-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30340-4"},{"key":"bibr5-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904398.)00188-0"},{"key":"bibr6-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32666-0"},{"key":"bibr7-09564624241288293","doi-asserted-by":"publisher","DOI":"10.7326\/M23-0788"},{"key":"bibr8-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.2985"},{"key":"bibr9-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2023.0250"},{"key":"bibr10-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13370"},{"key":"bibr11-09564624241288293","unstructured":"Felizarta F, D\u2019Amico R, Wang K. Thigh injections of cabotegravir + rilpivirine in virally suppressed adults with HIV-1. CROI. Seattle, WA, 2023. Poster 519."},{"key":"bibr12-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(23)00300-4"},{"key":"bibr14-09564624241288293","unstructured":"Hickey MD, Grochowski J, Mayorga-Munoz F, et al. 24-week viral suppression in patients starting long-acting CAB\/RPV without HIV viral suppression. In: CROI. Denver, CO, 2024. Poster 628."},{"key":"bibr15-09564624241288293","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxae216"},{"key":"bibr16-09564624241288293","unstructured":"Hill L, Yin J, Patel N, et al. Predictors of injection visit adherence in those receiving injectable cabotegravir\/rilpivirine. CROI. Denver, CO, 2024. Poster 624."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241288293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241288293","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241288293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:07Z","timestamp":1777675567000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241288293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/09564624241288293"],"URL":"https:\/\/doi.org\/10.1177\/09564624241288293","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}