{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:05:53Z","timestamp":1791137153424,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We sought to clarify the current incidence, risk factors and symptoms of disseminated Mycobacterium avium complex (dMAC) infection in admitted people living with HIV in a hospital in the Southeast of Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>5-years observational, retrospective and single-centre study. Demographic, clinical and analytical variables, along with microbiological, treatment and follow-up were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five cases of dMAC infection in severely immunocompromised people living with HIV people living were found. dMAC was diagnosed in 22.7% of patients under 100 CD4. All patients presented with fever and clinical manifestations of pneumonia, lymphadenopathy, or gastrointestinal symptoms. Despite low CD4 levels and high viral loads in some cases, primary prophylaxis had not been previously administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Until 2018, U.S. American guidelines recommended antimycobacterial prophylaxis for patients with low CD4 cell counts, a practice not adopted in Europe. Untreated dMAC infection is associated with high morbidity and mortality rates. dMAC infection represents a prevalent disease in severely immunosuppressed people living with HIV. dMAC requires a high index of suspicion in this population, in order to perform mycobacterial cultures from different samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241297835","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T15:30:47Z","timestamp":1730820647000},"page":"126-131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Mycobacterium avium<\/i>\n                    complex (MAC) infection in severely immunocompromised people living with HIV: Findings from a five-year cohort"],"prefix":"10.1177","volume":"36","author":[{"given":"Mar\u00eda del Roc\u00edo","family":"Fern\u00e1ndez-D\u00edaz","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naya","family":"Faro-Miguez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Aguilera-Franco","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Mu\u00f1oz-Medina","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Ruiz-Sancho","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rodr\u00edguez-Granger","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-6484","authenticated-orcid":false,"given":"Emilio","family":"Guirao-Arrabal","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Cl\u00ednico San Cecilio, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"bibr1-09564624241297835","volume-title":"Panel on guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: recommendations from the centers for disease control and prevention, the national institutes of health, and the HIV medicine association of the inf","year":"2019"},{"key":"bibr2-09564624241297835","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082541"},{"key":"bibr3-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1128\/9781555819866.ch40"},{"key":"bibr4-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1086\/314804"},{"key":"bibr5-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1086\/514014"},{"key":"bibr6-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-001-0634-8"},{"key":"bibr7-09564624241297835","unstructured":"GESIDA G de expertos del G de E de S de la S. Documento de Prevenci\u00f3n y Tratamiento de Infecciones Oportunistas y otras Coinfecciones en Pacientes con Infecci\u00f3n por VIH. Madrid: GESIDA-SEIMC. 2021. p. 1\u2013109. Available from: https:\/\/gesida-seimc.org\/wp-content\/uploads\/2022\/03\/GUIA_PREVENCION_INFECCIONES_OPORTUNISTAS.pdf"},{"key":"bibr8-09564624241297835","first-page":"1","author":"Centro Nacional de Epidemiologia","year":"2022","journal-title":"Sistema de Informaci\u00f3n Sobre Nuevos Diagn\u00f3sticos de VIH y Registro Nacional de Casos De Sida. Plan Nacional sobre el Sida"},{"key":"bibr9-09564624241297835","unstructured":"CLSI standard M24. Wayne PC and LSI. CLSI. Susceptibility testing of mycobacteria, nocardia spp. Other aerobic actinomycetes. 3rd ed. 2018."},{"issue":"4","key":"bibr10-09564624241297835","first-page":"E1","volume":"56","author":"Daley CL","year":"2020","journal-title":"Eur Respir J"},{"key":"bibr11-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0254607"},{"key":"bibr12-09564624241297835","unstructured":"Society EAC. Guidelines. Version 12.0. October 2023. Brussels: EACS - European AIDS Clinical Society, 2023, pp. 1\u2013162."},{"key":"bibr13-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2013.0270"},{"key":"bibr14-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000456"},{"key":"bibr15-09564624241297835","doi-asserted-by":"publisher","DOI":"10.1086\/323979"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241297835","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241297835","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241297835","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:10Z","timestamp":1777675570000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241297835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/09564624241297835"],"URL":"https:\/\/doi.org\/10.1177\/09564624241297835","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]}}}