{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:45:50Z","timestamp":1777927550559,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Oral HIV pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV, but its efficacy depends on adequate absorption of drug, which may decrease following gastrointestinal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinicians across eight Genito-urinary Medicine clinics in the United Kingdom submitted data on PrEP users with history of gastrointestinal surgery who were referred to a national complex PrEP multi-disciplinary team between June 2021 and April 2023. Anonymised data were submitted on demographics, surgical history, PrEP regimen, and results of therapeutic drug monitoring (TDM) and HIV screening tests. Descriptive analyses were performed in SPSS version 29.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine cases described cis-gender men-who-have-sex-with-men (MSM) with median age of 47.4 years (IQR = 43 \u2013 56.5) taking tenofovir disoproxil (TDF)\/emtricitabine (FTC) daily ( n = 8) or event-based ( n = 1) as PrEP. Median time between PrEP initiation and TDM was 53 days (IQR = 8.5\u20131705). The mean (\u00b1SD) trough concentration of tenofovir (TFV) and FTC were 90.2 \u00b1 27.7\u00a0ng\/mL and 76.0 \u00b1 45.9\u00a0ng\/mL, respectively. All patients had a negative HIV test at follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma trough concentrations of TFV observed in our cohort taking TDF\/FTC were above the expected concentrations associated with PrEP efficacy as previously described in the literature, suggesting that PrEP can be safely given in this population, with TDM used for reassurance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241298983","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:39:17Z","timestamp":1730828357000},"page":"250-254","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic drug monitoring of tenofovir disoproxil and emtricitabine in oral HIV pre-exposure prophylaxis (PrEP) users who have undergone gastrointestinal surgery"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-2568","authenticated-orcid":false,"given":"Muhammad Azam","family":"Ismail","sequence":"first","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Tittle","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Jones","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Loftus","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolo","family":"Girometti","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olamide","family":"Dosekun","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Stegmann","sequence":"additional","affiliation":[{"name":"Central London Community Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-7285","authenticated-orcid":false,"given":"Erica","family":"Pool","sequence":"additional","affiliation":[{"name":"UCL Institute for Global Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shema","family":"Tariq","sequence":"additional","affiliation":[{"name":"UCL Institute for Global Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Mortimer Market Centre, University College London Hospitals NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Tyler","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Coleman","sequence":"additional","affiliation":[{"name":"Guy\u2019s and St Thomas\u2019 NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-4932","authenticated-orcid":false,"given":"Yee Suh","family":"Teh","sequence":"additional","affiliation":[{"name":"Royal Berkshire Hospital, Reading, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Boffito","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"bibr1-09564624241298983","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-048478"},{"key":"bibr2-09564624241298983","first-page":"1","volume":"2112","author":"NHS England","year":"2023","journal-title":"Nhs"},{"key":"bibr3-09564624241298983","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000172"},{"key":"bibr4-09564624241298983","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12528"},{"key":"bibr5-09564624241298983","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1133415"},{"key":"bibr6-09564624241298983","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12755"},{"key":"bibr7-09564624241298983","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3319-4"},{"key":"bibr8-09564624241298983","unstructured":"NHS England. NHS England digital: national obesity audit. Available from: https:\/\/digital.nhs.uk\/data-and-information\/clinical-audits-and-registries\/national-obesity-audit#publications 2023."},{"key":"bibr9-09564624241298983","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002633"},{"issue":"1","key":"bibr10-09564624241298983","first-page":"e01902","volume":"65","author":"Calcagno A","year":"2021","journal-title":"Antimicrob Agents Chemother"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241298983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241298983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241298983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:11Z","timestamp":1777675571000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241298983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/09564624241298983"],"URL":"https:\/\/doi.org\/10.1177\/09564624241298983","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]}}}