{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:45:11Z","timestamp":1777927511483,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Approximately 50% of pregnant individuals treated for syphilis do not achieve a decline in non-treponemal titers by delivery. The serological response in pregnant persons is significantly slower compared to non-pregnant individuals, with unclear pathogenesis and clinical significance. This study aimed to determine the association between the host immune response and serological outcome in pregnant individuals with syphilis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-four females with early syphilis, including 14 pregnant individuals, were included. Pro-inflammatory and regulatory cytokines (IFN-\u03b3, TNF-\u03b1, IL-4, IL-1\u03b2, IL-10, TGF-\u03b2) were measured before treatment and 6 months after penicillin injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median time to serological cure was 5\u00a0months for pregnant individuals and 2\u00a0months for non-pregnant females. Pregnant individuals had significantly higher serum levels of IL-10 and TGF-\u03b2 at baseline and at 6\u00a0months post-treatment compared to non-pregnant individuals (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A robust regulatory immune response to syphilis may be associated with a slower serological response to therapy during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624241303816","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T22:27:01Z","timestamp":1733264821000},"page":"879-884","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Elevated IL-10 serum levels are associated with slower serological response following syphilis treatment during pregnancy"],"prefix":"10.1177","volume":"36","author":[{"given":"Martyna","family":"Kiolbasa","sequence":"first","affiliation":[{"name":"Clinical Department of Dermatology, Medical University of Silesia, Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Kotlarz","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Jagiellonian University Medical College, Krakow, Polnad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Kamini\u00f3w","sequence":"additional","affiliation":[{"name":"Clinical Department of Dermatology, Medical University of Silesia, Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7241-9685","authenticated-orcid":false,"given":"Maciej","family":"Pastuszczak","sequence":"additional","affiliation":[{"name":"Clinical Department of Dermatology, Medical University of Silesia, Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-018-0138-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv041"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2020.01.023"},{"key":"e_1_3_4_5_2","volume-title":"Sexually transmitted diseases treatment guidelines 2021","author":"Centers for Disease Control and Prevenation","year":"2021","unstructured":"Centers for Disease Control and Prevenation. Sexually transmitted diseases treatment guidelines 2021. Atlanta, GA: US Department of Health and Human Services, 2021."},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2024.119754"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/S1064744997000070"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu920"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-052681"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2011-050247"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1209-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00836.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150702"},{"key":"e_1_3_4_14_2","unstructured":"United States Centers for Disease Control and Prevention. Sexually transmitted disease surveillance. https:\/\/www.cdc.gov\/std\/statistics\/2019\/default.htm (2019)."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050622"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.1.69"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001717"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070102"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100615"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.17.05830-8"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-264"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.7.3135"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8028"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117031"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420515"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002528"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.06.010"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093320"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.05.003"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<119::AID-PD39>3.0.CO;2-T"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199702000-00007"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241303816","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241303816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241303816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:15Z","timestamp":1777675575000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241303816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":31,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/09564624241303816"],"URL":"https:\/\/doi.org\/10.1177\/09564624241303816","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]}}}