{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:44:55Z","timestamp":1777927495469,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>The resurgence of syphilis across Europe has led to a growing number of atypical cases, often characterised by varied symptoms that can delay diagnosis. We report the case of a young man who has sex with men (MSM), presenting with persistent headaches and swelling of the forehead suggestive of giant cell arteritis (GCA). Despite a recent negative syphilis test, further investigations confirmed the diagnosis of neurosyphilis. The patient had been using doxycycline post-exposure prophylaxis (DoxyPEP), which is suspected to have delayed the diagnosis by masking the typical antibody response. This case highlights concerns about DoxyPEP\u2019s impact on syphilis detection and disease progression. Further research is warranted to explore its effects on antimicrobial resistance, the human microbiome, and clinical outcomes.<\/jats:p>","DOI":"10.1177\/09564624241308026","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:59:45Z","timestamp":1734454785000},"page":"324-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["DOXY do, or DOXY Don\u2019t? Syphilis and doxycycline post-exposure prophylaxis: A case report"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7078-280X","authenticated-orcid":false,"given":"Omar","family":"Chircop","sequence":"first","affiliation":[{"name":"Department of Medicine, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5438-4596","authenticated-orcid":false,"given":"Courtney","family":"Jaggers","sequence":"additional","affiliation":[{"name":"General Medicine, Frimley Park Hospital NHS Foundation Trust, Frimley, Surrey, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Spiteri","sequence":"additional","affiliation":[{"name":"Accident and Emergency Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Schembri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-9230","authenticated-orcid":false,"given":"Valeska","family":"Padovese","sequence":"additional","affiliation":[{"name":"Genitourinary Clinic, Department of Dermatology and Venereology, Mater Dei Hospital, Msida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"European Centre for Disease Prevention and Control. Syphilis - annual epidemiological report for 2022. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/syphilis-annual-epidemiological-report-2022 (2024 accessed 29 September 2024)."},{"key":"e_1_3_4_3_2","volume-title":"StatPearls","author":"Ha T","year":"2024","unstructured":"Ha T, Tadi P, Leslie SW, et al. Neurosyphilis. In: StatPearls. Treasure Island, FL, 2024."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1340321"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.9779-22"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211934"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","unstructured":"CDC: Centers for Disease control and prevention CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention United States. https:\/\/www.cdc.gov\/mmwr\/volumes\/73\/rr\/rr7302a1.htm (2024 accessed on 1 October 2024).","DOI":"10.15585\/mmwr.rr7302a1"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054325"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad129"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241308026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624241308026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624241308026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:18Z","timestamp":1777675578000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624241308026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/09564624241308026"],"URL":"https:\/\/doi.org\/10.1177\/09564624241308026","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}