{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:46:14Z","timestamp":1777927574297,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The global burden of syphilis has remained persistently high with globally prevalent cases of syphilis, estimated to be 49.71 million in 2019. In India, where rates of syphilis screening remain sub-optimal, an accurate point-of-care (POC) test is convenient to carry out and guide immediate treatment. Here, we sought to evaluate the performance of an indigenous rapid POC test (Syphicheck -WB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was carried out in the serology laboratory of our tertiary care center over 2\u00a0months. Five hundred serum samples were chosen randomly. Performance parameters of the POC test were calculated in comparison to the\n                      <jats:italic toggle=\"yes\">Treponema pallidum<\/jats:italic>\n                      hemagglutination test, which was considered the reference standard.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and six samples (21.2%) were reactive for syphilis by the reference method (TPHA). The sensitivity and specificity of the POC test, were 81.13% and 98.48% respectively. The sensitivity and specificity of the reverse algorithm using POC test for screening, were 81.13% and 99.75% respectively, and of the traditional algorithm using VDRL were 77.36% and 100% respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This POC test is a promising candidate as a rapid treponemal screening test. It is likely to improve screening for syphilis under both laboratory as well as field conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624251358285","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T20:48:02Z","timestamp":1752266882000},"page":"923-929","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Paving the way for syphilis reverse algorithm diagnostic strategy in the Indian scenario through treponemal POCT"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6254-8752","authenticated-orcid":false,"given":"Maitrayee","family":"Narayan","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-1543","authenticated-orcid":false,"given":"Hitender","family":"Gautam","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyam","family":"Batra","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1970-5046","authenticated-orcid":false,"given":"Bimal Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"issue":"1","key":"e_1_3_5_2_2","first-page":"4","article-title":"Brief history of syphilis","volume":"7","author":"Tampa M","year":"2014","unstructured":"Tampa M, Sarbu I, Matei C, et al. Brief history of syphilis. J Med Life 2014; 7(1): 4\u201310.","journal-title":"J Med Life"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-38294-4"},{"key":"e_1_3_5_4_2","unstructured":"World Health Organization. (2025). Syphilis. WHO. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/syphilis [Accessed 3rd July 2025]."},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.10.010504"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219613"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00221-7"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_788_22"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2015.12.007"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijstd.ijstd_100_22"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu087"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa307"},{"key":"e_1_3_5_13_2","volume-title":"National guidelines on prevention, management and control of reproductive tract infections and sexually transmitted infections","author":"National AIDS Control Organization","year":"2014","unstructured":"National AIDS Control Organization. National guidelines on prevention, management and control of reproductive tract infections and sexually transmitted infections. New Delhi: NACO, Ministry of Health and Family Welfare, Government of India, 2014."},{"key":"e_1_3_5_14_2","volume-title":"The national strategy & operational guidelines towards elimination of congenital syphilis","author":"National AIDS Control Organization","year":"2015","unstructured":"National AIDS Control Organization. The national strategy & operational guidelines towards elimination of congenital syphilis. New Delhi: NACO, Ministry of Health and Family Welfare, Government of India, 2015."},{"issue":"1","key":"e_1_3_5_15_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7301a1","article-title":"CDC laboratory recommendations for syphilis testing, United States, 2024","volume":"73","author":"Papp JR","year":"2024","unstructured":"Papp JR, Park IU, Fakile Y, et al. CDC laboratory recommendations for syphilis testing, United States, 2024. MMWR Recomm Rep (Morb Mortal Wkly Rep) 2024; 73(RR-1): 1\u201332.","journal-title":"MMWR Recomm Rep (Morb Mortal Wkly Rep)"},{"key":"e_1_3_5_16_2","volume-title":"National AIDS control organization","author":"National Technical Guidelines on Sexually Transmitted Infections and Reproductive Tract Infections","year":"2024","unstructured":"National Technical Guidelines on Sexually Transmitted Infections and Reproductive Tract Infections. National AIDS control organization. New Delhi: National AIDS Control Organization (NACO), 2024."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138172"},{"issue":"4","key":"e_1_3_5_18_2","first-page":"208","article-title":"Syphilis point-of-care tests (POCTs): implementation considerations in Canada","volume":"9","author":"Whyte K","year":"2024","unstructured":"Whyte K, Chittle A, Tsang RSW. Syphilis point-of-care tests (POCTs): implementation considerations in Canada. Can J Infect Dis Med Microbiol 2024; 9(4): 208\u2013218.","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"3","key":"e_1_3_5_19_2","first-page":"166","article-title":"Modified BG Prasad and modified Kuppuswami socio-economic status scales: revision and updates for january 2024","volume":"1","author":"Mohanty M","year":"2024","unstructured":"Mohanty M, Patle RA, Narlawar UW. Modified BG Prasad and modified Kuppuswami socio-economic status scales: revision and updates for january 2024. PMRR 2024; 1(3): 166\u2013167.","journal-title":"PMRR"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.1.1"},{"key":"e_1_3_5_21_2","volume-title":"Practices of infectious diseases","author":"Mandell D","year":"2020","unstructured":"Mandell D, Principles B. Practices of infectious diseases. 9th ed. 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