{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:46:14Z","timestamp":1777927574439,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several antiretroviral regimens have been used for prevention of mother to child transmission (MTCT) of HIV, with maternal dolutegravir-based regimens (e.g. tenofovir\/lamivudine\/dolutegravir - TLD) being the latest, initiated in last 3\u20134\u00a0years. There is a need for assessment of effectiveness of this new regimen as compared to earlier efavirenz-based (tenofovir\/lamivudine\/efavirenz - TLE) and other regimens in program settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted this retrospective cohort study to determine effectiveness of the TLD regimen in preventing antenatal, intranatal and postnatal MTCT compared to earlier regimens. 1905 HIV-exposed infants in West Bengal, India from April 2017 to March 2023 with available polymerase chain reaction for HIV at 314 Integrated Counselling and Testing Centres were considered. Duration of antenatal antiretroviral treatment and infant feeding practices types were also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among all mothers, 666 (35%) received TLD and 1194 (63%) TLE. With TLD, MTCT rate was significantly lower (2% vs 6.5%) [Adjusted Odds Ratio (AOR) = 0.28; 0.15\u20130.52] than all other regimens. Duration of maternal antiretroviral therapy (weeks) (AOR = 0.96; 0.95\u20130.98) and infant feeding practices (AOR = 0.09; 0.03\u20130.25) showed significant association with reduced MTCT rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dolutegravir-based ART is more effective than earlier regimens and promises to achieve the elimination of pediatric HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624251361183","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T06:20:55Z","timestamp":1754115655000},"page":"994-999","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of dolutegravir based antiretroviral treatment in preventing vertical transmission of HIV in West Bengal, India: A retrospective cohort study"],"prefix":"10.1177","volume":"36","author":[{"given":"Suman","family":"Ganguly","sequence":"first","affiliation":[{"name":"West Bengal State AIDS Prevention & Control Society"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-7475","authenticated-orcid":false,"given":"Debjit","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"ICMR- National Institute of Cholera and Enteric Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falguni","family":"Debnath","sequence":"additional","affiliation":[{"name":"ICMR- National Institute of Cholera and Enteric Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sombuddha","family":"Biswas","sequence":"additional","affiliation":[{"name":"ICMR- National Institute of Cholera and Enteric Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-7604","authenticated-orcid":false,"given":"Mihir","family":"Bhatta","sequence":"additional","affiliation":[{"name":"ICMR- National Institute of Cholera and Enteric Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-3971","authenticated-orcid":false,"given":"Agniva","family":"Majumdar","sequence":"additional","affiliation":[{"name":"ICMR- National Institute of Cholera and Enteric Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok Kumar","family":"Deb","sequence":"additional","affiliation":[{"name":"ICMR- National Institute of Cholera and Enteric Disease"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"India HIV Estimates 2023 Technical Report Available at https:\/\/naco.gov.in\/sites\/default\/files\/IndiaHIVEstimates2023_TechnicalReport_Final_17DEC202428129.pdf"},{"key":"e_1_3_4_3_2","unstructured":"WHO recommends dolutegravir as preferred HIV treatment option in all populations. Available at https:\/\/www.who.int\/news\/item\/22-07-2019-who-recommends-dolutegravir-as-preferred-hiv-treatment-option-in-all-populations."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30050-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00173-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001755"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30400-X"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325957413488176"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2013.0059"},{"key":"e_1_3_4_10_2","unstructured":"Recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission in the United States. Available at: https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/perinatal\/recommendations-arv-drugs-pregnancy-prevent-hiv-improve-maternal-health. (accessed 4th January 2025)."},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002338"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-6154-6"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233341"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.21276\/aimdr.2016.2.5.CM1"},{"key":"e_1_3_4_15_2","unstructured":"Updated guideline for prevention of parent to child transmission (PPTCT) of HIV using multi drug anti-retroviral regimen in India. Available at: https:\/\/naco.gov.in\/sites\/default\/files\/National_Guidelines_for_PPTCT.pdf. (accessed 4th January 2025.)"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.5114\/hivar.2018.76366"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/09564624221076618"},{"issue":"4","key":"e_1_3_4_18_2","first-page":"421","article-title":"The outcome of prevention of mother to child transmission (PMTCT) of HIV infection programme in Nnewi, southeast Nigeria","volume":"20","author":"Ikechebelu JI","year":"2011","unstructured":"Ikechebelu JI, Ugboaja JO, Kalu SO, et al. The outcome of prevention of mother to child transmission (PMTCT) of HIV infection programme in Nnewi, southeast Nigeria. Niger J Med 2011; 20(4): 421\u2013425.","journal-title":"Niger J Med"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251361183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624251361183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251361183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:46:53Z","timestamp":1777675613000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624251361183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":17,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/09564624251361183"],"URL":"https:\/\/doi.org\/10.1177\/09564624251361183","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}