{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:45:35Z","timestamp":1777927535994,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Single-tablet regimens (STRs) with integrase inhibitors, bictegravir (BIC) or dolutegravir (DTG), are favored in HIV treatment for their efficacy and convenience. This study compares persistence\u2014time from initiation to discontinuation\u2014between BIC\/emtricitabine (FTC)\/tenofovir alafenamide (TAF) and DTG-containing STRs at a Toronto HIV clinic\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort analysis was conducted on 1732 adults with HIV at Maple Leaf Medical Clinic who initiated or switched to BIC\/FTC\/TAF or DTG-containing STRs from 2016 to 2022. Persistence was measured in days until discontinuation. Kaplan-Meier curves and Cox models evaluated time-to-discontinuation and associated risks. Reasons for discontinuation were categorized into adverse events, patient preference, cost, compliance, physician preference, virologic failure, and others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1732 participants (median age 48\u00a0years, 88.7% cisgender men), 387 (22.3%) discontinued their STRs after a median of 402\u00a0days. BIC\/FTC\/TAF had a lower discontinuation rate (18.9%) compared to DTG-containing STRs (29.9%) (HR = 0.74, 95% CI: 0.60\u20130.92). Adverse events were the primary reason for discontinuation, with BIC having lower rates (9.6% vs. 12.5% for DTG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>BIC\/FTC\/TAF demonstrated higher persistence and fewer adverse events than DTG-containing STRs, aiding personalized HIV treatment decisions for better long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624251371800","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T12:07:21Z","timestamp":1756123641000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world persistence of bictegravir versus dolutegravir single-tablet regimens: A retrospective cohort study in a large urban Canadian HIV clinic"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-8997","authenticated-orcid":false,"given":"Mona","family":"Loutfy","sequence":"first","affiliation":[{"name":"Maple Leaf Medical Clinic"},{"name":"Women\u2019s College Hospital"},{"name":"University of Toronto"},{"name":"University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Masoudifar","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"McCully","sequence":"additional","affiliation":[{"name":"Maple Leaf Medical Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Underhill","sequence":"additional","affiliation":[{"name":"Maple Leaf Medical Clinic"},{"name":"Women\u2019s College Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7478-8596","authenticated-orcid":false,"given":"V Logan","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Maple Leaf Medical Clinic"},{"name":"Women\u2019s College Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dileesha","family":"Fernando","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylana","family":"Mumm","sequence":"additional","affiliation":[{"name":"Gilead Sciences Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taban","family":"Saifi","sequence":"additional","affiliation":[{"name":"Gilead Sciences Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Ngo","sequence":"additional","affiliation":[{"name":"Gilead Sciences Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soodi","family":"Navadeh","sequence":"additional","affiliation":[{"name":"Gilead Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Smith","sequence":"additional","affiliation":[{"name":"Maple Leaf Medical Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000082"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/13596535211062396"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328340a209"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv083"},{"key":"e_1_3_8_6_2","unstructured":"National Institutes of Health. 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