{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:57:16Z","timestamp":1789088236374,"version":"build-2803163510"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    In 2024, national guidance was issued for doxycycline post-exposure prophylaxis (doxy-PEP) to prevent bacterial sexually transmitted infections (STIs). The study purpose was to evaluate doxy-PEP use in patients with increased risk of STI exposure at a large, urban health system.\u00a0\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    IRB-exempt study of adult patients with clinic encounters for increased risk of STI exposure and testing for\n                    <jats:italic toggle=\"yes\">N. gonorrhoeae<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">T. pallidum<\/jats:italic>\n                    from 01\/01\/2023-31\/10\/2024. Patients were identified using ICD-10 code Z20.XX and STI testing. Doxy-PEP prescription utilization was evaluated after a dedicated doxy-PEP order was implemented with appropriate patient counseling instructions. The primary outcome was the proportion of doxy-PEP prescriptions utilized in at-risk patients; secondary outcomes were utilization of the dedicated doxy-PEP order and abnormal STI testing within 3-months of the doxy-PEP prescription.\u00a0\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    4234 high-risk sexual patient encounters were documented; 7.37% of patients received a doxy-PEP prescription. Of these, 29.5% were ordered utilizing a dedicated doxy-PEP order. Most patients who received a doxy-PEP prescription were Black (96.6%), men (92.6%), with a median (IQR) age of 29 (24-37) years, and had private\/commercial insurance (42%). One patient had abnormal syphilis testing within 3-months of doxy-PEP prescription.\u00a0\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These findings highlight doxy-PEP underutilization and the need for broader provider engagement and advanced antimicrobial stewardship interventions.\n                  <\/jats:p>","DOI":"10.1177\/09564624251379701","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T22:56:27Z","timestamp":1757976987000},"page":"192-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A cross-sectional analysis of doxyPEP use and outcomes in Michigan, United States"],"prefix":"10.1177","volume":"37","author":[{"given":"Christen J","family":"Arena","sequence":"first","affiliation":[{"name":"Henry Ford Hospital"},{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A","family":"Everson","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M","family":"Kenney","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Brar","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-8268","authenticated-orcid":false,"given":"Smitha","family":"Gudipati","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Yared","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L","family":"Davis","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-5211","authenticated-orcid":false,"given":"Michael P","family":"Veve","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital"},{"name":"Wayne State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Slides from STI surveillance, 2023","author":"Centers for Disease Control and Prevention (CDC)","unstructured":"Centers for Disease Control and Prevention (CDC). Slides from STI surveillance, 2023. CDC. https:\/\/www.cdc.gov\/sti-statistics\/annual\/slides.html (Published November 12, 2024. Accessed June 25, 2025)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7302a1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30725-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211934"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00236-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0949"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1197\/jamia.M1370"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00234-8"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2024-056388"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2024-056261"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00235-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-025-00726-3"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251379701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624251379701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251379701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:47:07Z","timestamp":1777675627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624251379701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/09564624251379701"],"URL":"https:\/\/doi.org\/10.1177\/09564624251379701","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,15]]}}}