{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:46:24Z","timestamp":1777927584390,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100016003","name":"Istanbul \u00dcniversitesi-Cerrahpasa","doi-asserted-by":"publisher","award":["TTU-2022-36595."],"award-info":[{"award-number":["TTU-2022-36595."]}],"id":[{"id":"10.13039\/501100016003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to determine the effect of combined antiretroviral therapy (cART) on hepatic steatosis and fibrosis in people living with human immunodeficiency virus (PLwHIV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center and prospective cohort study, PLwHIV were evaluated longitudinally by transient elastography at the initiation and 7\u00a0months (\u00b11\u00a0month) after the cART.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 81 PLwHIV, 28.3% had hepatic steatosis, 40.7% had fibrosis (\u2265F1), and 24.7% had significant fibrosis (\u2265F2). In multivariate analysis, body mass index (BMI) (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .005) and albumin (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .045) were independent predictors for hepatic steatosis, while aspartate aminotransferase (AST) (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .041) was an independent predictor for hepatic fibrosis. Control transient elastography was performed in 66 (81.5%) PLwHIV after treatment. Among these patients, the rate of hepatic fibrosis decreased significantly after treatment (43.9% vs 24.2%,\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .017). In the tenofovir alafenamide (TAF)-based regimen, weight (\n                      <jats:italic toggle=\"yes\">p &lt;<\/jats:italic>\n                      .001), BMI (\n                      <jats:italic toggle=\"yes\">p &lt;<\/jats:italic>\n                      .001), waist circumference (\n                      <jats:italic toggle=\"yes\">p &lt;<\/jats:italic>\n                      .001), and total cholesterol (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .012) increased, while kPA value (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .002) decreased. In the tenofovir disoproxil fumarate (TDF)-based regimen, controlled attenuation parameter (CAP) value (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .017) and waist circumference (\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      .006) increased. In the lamivudine (LAM)-based regimen, there was no statistically significant change (p &gt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatic fibrosis regressed with antiretroviral treatments (especially with TAF-based), while the degree of hepatosteatosis progressed (especially with TDF-based). Additionally, weight gain occurred after cART in PLwHIV (especially with TAF-based). Therefore, hepatic steatosis and weight gain in PLwHIV should not be disregarded. In conclusion, PLwHIV on cART need close follow-up for the development of metabolic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624251382627","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:28:26Z","timestamp":1758673706000},"page":"158-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of cART on hepatic steatosis and fibrosis in treatment-na\u00efve PLwHIV: A prospective cohort study"],"prefix":"10.1177","volume":"37","author":[{"given":"Meryem","family":"Sahin Ozdemir","sequence":"first","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-5091","authenticated-orcid":false,"given":"Yusuf Emre","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Bakirkoy Dr Sadi Konuk Training and Research 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