{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:49:18Z","timestamp":1781214558961,"version":"3.54.1"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                    is the most prevalent bacterial sexually transmitted infection (STI) worldwide, often asymptomatic in women and associated with severe reproductive complications. In Brazil, population-based screening is not routinely implemented. This study aimed to evaluate the cost-effectiveness of\n                    <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                    screening among asymptomatic women in different age groups.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A hypothetical cohort of 10,000 women was simulated in a Markov model over 10\u00a0years, stratified into three age groups: 14\u201325, 26\u201330, and 31\u201335\u00a0years. We compared three screening strategies: annual screening, screening every three to 4\u00a0years, and no screening. Clinical outcomes included pelvic inflammatory disease (PID), infertility, ectopic pregnancy, and chronic pelvic pain. Costs were presented in Brazilian Reals (BRL) and U.S. Dollars (USD), and the main outcome was the incremental cost-effectiveness ratio (ICER) per significant case averted.\n                    <jats:bold>Results:<\/jats:bold>\n                    Annual screening in women aged 14\u201325 was the most cost-effective strategy, preventing 7,274 significant health outcomes at a total cost of R$ 7.39 million (USD 1.48 million), resulting in an ICER of R$ 1,015 (USD 203) per case averted. For women aged 26\u201330, screening every 3\u00a0years was more cost-effective, while for those aged 31\u201335, screening every 4\u00a0years yielded the best value for money.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    targeted chlamydia screening strategies by age group are cost-effective in Brazil. Annual screening of women aged \u226425\u00a0years, in particular, offers substantial health benefits at acceptable costs and should be prioritized in STI control programs.\n                  <\/jats:p>","DOI":"10.1177\/09564624251396311","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:12:53Z","timestamp":1763104373000},"page":"347-354","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost effectiveness of\n                    <i>Chlamydia trachomatis<\/i>\n                    screening in women in Brazil"],"prefix":"10.1177","volume":"37","author":[{"given":"Telma R.","family":"de M\u00f4naco e Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Bittencourt","family":"Campaner","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Castro","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-7143","authenticated-orcid":false,"given":"Adrienne Pratti","family":"Lucarelli","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_3_4_2_2","unstructured":"World Health Organization. Chlamydia. [Internet]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chlamydia [cited 2024 Nov]."},{"key":"e_1_3_4_3_2","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). https:\/\/www.gov.br\/saude\/pt-br\/assuntos\/noticias. [Internet]. [cited 2023 Feb]."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.30"},{"key":"e_1_3_4_5_2","unstructured":"Guidelines for the management of asymptomatic sexually transmitted infections. Available: https:\/\/iris.who.int\/handle\/10665\/381533"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.024364"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000542685"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2020.10.024"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(24)00266-3"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13584-017-0141-8"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10441-020-09401-z"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251396311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624251396311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251396311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:47:18Z","timestamp":1777675638000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624251396311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/09564624251396311"],"URL":"https:\/\/doi.org\/10.1177\/09564624251396311","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]}}}