{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:46:36Z","timestamp":1777927596881,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Kocaeli University has an open access agreement with Sage for article processing charges."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This multicentre study evaluated the prevalence, distribution, and risk factors of cancer among people living with HIV (PLWH) in Turkey over two decades. Mortality rates and factors were also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 154 adults diagnosed with cancer and HIV between 2008 and 2024. Data were collected from the medical records. The demographics, clinical characteristics, cancer types, treatments, and outcomes were evaluated. The risk factors for ADCs and mortality were defined using multivariate logistic regression and Cox regression. The estimated survival time was determined using Kaplan-Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 8708 PLWH, cancer prevalence was 1.8% (95% CI:1.5-2). ADCs (66.9%) were twice as frequent as NADCs (33.1%). Most prevalent cancers were non-Hodgkin lymphoma (35.1%), Kaposi sarcoma (29.9%), and lung cancer (7.8%). Age \u226454 years, CD4 + T lymphocyte count \u226494\/mm\n                      <jats:sup>3<\/jats:sup>\n                      , and HHV-8 co-infection were risk factors for ADCs. Mortality rate was 32%. Non-Hodgkin lymphoma and CD4 + T lymphocyte count \u2264232\/mm\n                      <jats:sup>3<\/jats:sup>\n                      at treatment completion predicted mortality. The 3-years overall survival rate was 67.6%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study offers insights into cancer burden among PLWH in Turkey. High rates of ADCs and mortality highlight the importance of early HIV diagnosis and antiretroviral therapy access to reduce cancer burden in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624251405965","type":"journal-article","created":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T13:44:11Z","timestamp":1765115051000},"page":"500-510","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-7224","authenticated-orcid":false,"given":"\u00d6zlem","family":"G\u00fcler","sequence":"first","affiliation":[{"name":"Kocaeli University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0131la","family":"Akhan","sequence":"additional","affiliation":[{"name":"Kocaeli University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atahan","family":"\u00c7a\u011fatay","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Bat\u0131rel","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Sarg\u0131n Altunok","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-3894","authenticated-orcid":false,"given":"Sibel","family":"Boluk\u00e7u","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya","family":"\u00d6zkan \u00d6zdemir","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine \u0130lay","family":"Duman","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-2727","authenticated-orcid":false,"given":"M\u00fcge","family":"Toygar Deniz","sequence":"additional","affiliation":[{"name":"Kocaeli University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"\u00d6zyi\u011fito\u011flu","sequence":"additional","affiliation":[{"name":"Abdulhamid Han Education and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemalettin","family":"\u00d6zden","sequence":"additional","affiliation":[{"name":"Atat\u00fcrk University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Alay","sequence":"additional","affiliation":[{"name":"Atat\u00fcrk University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Seyman","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melda","family":"T\u00fcrken","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eebnem","family":"\u00c7al\u0131k","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zge","family":"\u00c7ayda\u015f\u0131","sequence":"additional","affiliation":[{"name":"Health Sciences University Sancaktepe \u015eehit Prof.Dr \u0130lhan Varank Education And Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"\u00d6zt\u00fcrk Engin","sequence":"additional","affiliation":[{"name":"Health Sciences University Sancaktepe \u015eehit Prof.Dr \u0130lhan Varank Education And Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zg\u00fcr","family":"G\u00fcnal","sequence":"additional","affiliation":[{"name":"Samsun University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeyma","family":"Topal","sequence":"additional","affiliation":[{"name":"Samsun University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O\u011fuz","family":"Karabay","sequence":"additional","affiliation":[{"name":"Sakarya University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Sar\u0131g\u00fcl","sequence":"additional","affiliation":[{"name":"Antalya Life Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-6755","authenticated-orcid":false,"given":"Hanife Nur","family":"Karako\u00e7 Parlayan","sequence":"additional","affiliation":[{"name":"Karadeniz Technical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fin","family":"K\u0131l\u0131n\u00e7 Toker","sequence":"additional","affiliation":[{"name":"Kayseri City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Bayhan","sequence":"additional","affiliation":[{"name":"Ad\u0131yaman Education and Research Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar","family":"Ergen","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"\u0130nce","sequence":"additional","affiliation":[{"name":"D\u00fczce University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eafak","family":"Kaya","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcan","family":"Arslan \u00d6zel","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aybeg\u00fcm","family":"\u00d6z\u015fahin","sequence":"additional","affiliation":[{"name":"Recep Tayyip Erdo\u011fan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Health Sciences University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Gaziantep Islam Science and Technology University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Balc\u0131","sequence":"additional","affiliation":[{"name":"Kocaeli University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckran","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Dokuz Eyl\u00fcl University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2025.102661"},{"key":"e_1_3_8_3_2","first-page":"e495","article-title":"Spectrum of cancer risk among HIV-Infected people in the United States during the modern antiretroviral therapy era: a population-based registry linkage study","volume":"4","author":"Hern\u00e1ndez-Ram\u00edrez RU","year":"2017","unstructured":"Hern\u00e1ndez-Ram\u00edrez RU, Shiels MS, Dubrow R, et al. Spectrum of cancer risk among HIV-Infected people in the United States during the modern antiretroviral therapy era: a population-based registry linkage study. Lancet HIV 2017; 4: e495\u2013e504.","journal-title":"Lancet HIV"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30179-6"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20220012"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16010070"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0964"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1016"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101613"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60081357"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1364341"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_8_13_2","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2023","unstructured":"R Core Team. R: a language and environment for statistical computing. : R Foundation for Statistical Computing, 2023. https:\/\/www.R-project.org"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.26719\/emhj.19.030"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34166"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/17455057231170061"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2022.2074957"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.17843\/rpmesp.2021.382.6341"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0317222"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16387-z"},{"key":"e_1_3_8_21_2","unstructured":"2015_eacsguidelines_8_0-english_rev-20160124.pdf. https:\/\/www.eacsociety.org\/media\/2015_eacsguidelines_8_0-english_rev-20160124.pdf (accessed 26 September 2025)."},{"key":"e_1_3_8_22_2","unstructured":"EACS Guidelines. EACS guidelines. https:\/\/eacs.sanfordguide.com (2024) accessed 26 September 2025."},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003389"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr076"},{"key":"e_1_3_8_25_2","unstructured":"Kanser \u0130statistikleri. https:\/\/hsgm.saglik.gov.tr\/tr\/kanser-istatistikleri (accessed 29 March 2025)."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251405965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624251405965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624251405965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:47:22Z","timestamp":1777675642000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624251405965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/09564624251405965"],"URL":"https:\/\/doi.org\/10.1177\/09564624251405965","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,7]]}}}