{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:10:38Z","timestamp":1788412238999,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Syphilis notifications, including congenital syphilis, have increased markedly in recent years across the European Union\/European Economic Area (EU\/EEA), raising renewed public health concerns. This study aimed to characterise long-term trends in adult syphilis notifications in the EU\/EEA from 2000 to 2023 and to examine recent patterns in congenital syphilis using joinpoint regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Annual crude notification rates for adult syphilis (per 100,000 population, 2000\u20132023) and congenital syphilis (per 100,000 live births, 2010\u20132023) were obtained from the ECDC Surveillance Atlas. Joinpoint regression was applied to identify significant trend changes, estimate Annual Percent Change (APC) and, where appropriate, Average Annual Percent Change (AAPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the EU\/EEA, adult syphilis rates declined from 2000 to 2007 (APC \u20138.76%), increased from 2007 to 2021 (APC +3.32%), and rose sharply after 2021 (APC +24.65%). Overall AAPC (2000\u20132023) was +1.12%. Congenital syphilis rates declined between 2010 and 2016 (APC \u201311.92%), then increased between 2016 and 2023 (APC +9.16%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Syphilis notifications in the EU\/EEA show a sustained resurgence, with recent acceleration and a parallel rising trend in congenital syphilis. Reinforcement of STI screening, timely treatment, and strengthened antenatal care are urgently warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624261420693","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:37:27Z","timestamp":1770064647000},"page":"623-629","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiological trends in adult and congenital syphilis in the EU\/EEA: A joinpoint study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6724-1488","authenticated-orcid":false,"given":"Zeynep Sedef","family":"Varol","sequence":"first","affiliation":[{"name":"Izmir Democracy University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Syphilis\u2013annual epidemiological report for 2023","author":"European Centre for Disease Prevention and Control","year":"2024","unstructured":"European Centre for Disease Prevention and Control. Syphilis\u2013annual epidemiological report for 2023. ECDC, 2024. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/syphilis-annual-epidemiological-report-2023 (Accessed 10 November 2025)."},{"key":"e_1_3_5_3_2","volume-title":"Annual epidemiological report for 2023","author":"European Centre for Disease Prevention and Control","year":"2025","unstructured":"European Centre for Disease Prevention and Control. Congenital syphilis. In: Annual epidemiological report for 2023. ECDC, 2025. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/congenital-syphilis-annual-epidemiological-report-2023 (Accessed 10 November 2025)."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7246e1"},{"key":"e_1_3_5_5_2","article-title":"Thirty-year trend of syphilis during the periods of resurgence, HIV risk compensation and COVID-19 pandemic (1991\u20132022)","author":"Giuliani M","year":"2025","unstructured":"Giuliani M, Latini A, Palamara G, et al. Thirty-year trend of syphilis during the periods of resurgence, HIV risk compensation and COVID-19 pandemic (1991\u20132022). Sex Transm Dis 2025. Published online.","journal-title":"Sex Transm Dis"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-15510-4"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3733"},{"key":"e_1_3_5_9_2","volume-title":"Joinpoint regression program\u2013software and methods","author":"US National Cancer Institute","unstructured":"US National Cancer Institute. Joinpoint regression program\u2013software and methods. https:\/\/surveillance.cancer.gov\/joinpoint\/ (Accessed 2 November 2025)."},{"key":"e_1_3_5_10_2","volume-title":"Surveillance atlas of infectious diseases\u2013syphilis (dataset)","author":"European Centre for Disease Prevention and Control","year":"2024","unstructured":"European Centre for Disease Prevention and Control. Surveillance atlas of infectious diseases\u2013syphilis (dataset). 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