{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T21:54:29Z","timestamp":1781906069428,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Treatment for\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      include azithromycin and doxycycline; however, comparative studies in cis-male populations remain limited. This systematic review and meta-analysis assessed the efficacy and safety of azithromycin versus doxycycline for treating chlamydial infections among cis-men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed\/MEDLINE, Embase, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, CINAHL, and Google Scholar. Randomized controlled trials comparing doxycycline (100\u00a0mg twice daily for 7\u00a0days) with azithromycin (1\u00a0g single dose) in cis-men infected with\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      were included. Risk of bias was assessed using the Cochrane RoB 2 tool and meta-analysis was reported in accordance with the PRISMA 2020 guidelines. The primary outcome was microbiological cure at last follow-up. Pooled effect estimates were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) using the random-effects model. Subgroup, meta-regression, publication bias and sensitivity analyses were performed. The protocol was registered in PROSPERO (CRD42024535957).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      10 randomized controlled trials comprising 1172 cis-male participants were included. Overall, 560\/602 (93%) participants treated with doxycycline and 504\/627 (81%) treated with azithromycin achieved microbiological cure. Meta-analysis demonstrated significantly higher odds of cure with doxycycline compared with azithromycin (OR = 2.525, 95% CI = 1.329\u20134.796,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.005). Adverse events were not significantly different between groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.757). Subgroup analysis showed significant superiority of doxycycline for rectal infection and chlamydia-associated nongonococcal urethritis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), but not for prostate infection (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.745). Sensitivity analysis demonstrated strong reliability and no statistical evidence of publication bias (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Doxycycline demonstrated superior microbiological efficacy compared with azithromycin in cis-men with\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      . However, moderate heterogeneity was detected across studies and data for rectal and prostate infections were limited. Consequently, further well-designed trials are required to confirm these findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624261435919","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:02:31Z","timestamp":1774443751000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of doxycycline versus azithromycin for the treatment of\n                    <i>Chlamydia trachomatis<\/i>\n                    in cis-men: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-0519","authenticated-orcid":false,"given":"Safa","family":"Boujemaa","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Biologica Training and Consulting"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurparsad Singh","family":"Suri","sequence":"additional","affiliation":[{"name":"Lincoln Memorial University-DeBusk College of Osteopathic Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Bluefield University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"World Health Organization. Sexually transmitted infections (STIs) [internet]. 2022 [cited 2025 Oct 10]. 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