{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:10:51Z","timestamp":1790097051930,"version":"4.0.1"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Worldwide,\n                      <jats:italic toggle=\"yes\">Mycoplasma genitalium<\/jats:italic>\n                      infections are becoming more resistant to both macrolides and fluoroquinolones - termed multi-drug-resistant (MDR) infections. Combination therapy has shown promise in treating other MDR pathogens. We have previously reported the first five cases of MDR\n                      <jats:italic toggle=\"yes\">M. genitalium<\/jats:italic>\n                      urethritis successfully treated with a novel combination therapy regimen consisting of minocycline, metronidazole, methenamine and pristinamycin (\u2018M3P\u2019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We describe a second case series of four individuals treated with M3P as salvage therapy for\n                      <jats:italic toggle=\"yes\">M. genitalium<\/jats:italic>\n                      urethritis. Clinical data, laboratory findings, resistance profiles, and treatment outcomes were reviewed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All four individuals had persistent\n                      <jats:italic toggle=\"yes\">M. genitalium<\/jats:italic>\n                      urethritis and evidence of macrolide and fluoroquinolone resistance. Prior treatments included multiple courses of doxycycline, minocycline, azithromycin, fluoroquinolones, pristinamycin and other salvage regimens. Treatment with M3P for 14 days was associated with complete resolution of symptoms and negative post-treatment\n                      <jats:italic toggle=\"yes\">M. genitalium<\/jats:italic>\n                      nucleic acid amplification tests in all four cases. No adverse effects were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      M3P is a useful salvage therapy for MDR\n                      <jats:italic toggle=\"yes\">M. genitalium<\/jats:italic>\n                      infections that do not respond to other regimens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624261485264","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:25:43Z","timestamp":1789809943000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Methenamine, minocycline, metronidazole and pristinamycin (M3P) for multi-drug-resistant\n                    <i>Mycoplasma genitalium<\/i>\n                    urethritis: A case series"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-6041","authenticated-orcid":false,"given":"Thibaut","family":"Vanbaelen","sequence":"first","affiliation":[{"name":"Institute of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-252X","authenticated-orcid":false,"given":"Irith","family":"De Baetselier","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-5137","authenticated-orcid":false,"given":"Sheeba Santhini","family":"Manoharan-Basil","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorien","family":"Van Den Bossche","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-2297","authenticated-orcid":false,"given":"Izumo","family":"Kanesaka","sequence":"additional","affiliation":[{"name":"Toho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-8998","authenticated-orcid":false,"given":"Chris","family":"Kenyon","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine"},{"name":"University of Cape Town"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2024.29.7.2300318"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17972"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaf142"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad427"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00006-23"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2025-056517"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2895"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810004115"}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624261485264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624261485264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624261485264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:51:03Z","timestamp":1790095863000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624261485264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":8,"alternative-id":["10.1177\/09564624261485264"],"URL":"https:\/\/doi.org\/10.1177\/09564624261485264","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]},"article-number":"09564624261485264"}}