{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:09:48Z","timestamp":1789063788901,"version":"build-2803163510"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J STD AIDS"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Lymphogranuloma venereum (LGV), caused by\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      L-genotypes, has re-emerged as a major anorectal infection in men who have sex with men (MSM), especially in people living with HIV. Distinguishing LGV from non-LGV\n                      <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                      is essential because LGV requires 3\u00a0weeks of doxycycline. Long-term Latin American data are lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Anorectal swabs from patients with suspected anorectal sexually transmitted infections were studied in a cross-sectional study conducted at two Buenos Aires coloproctology referral centers (August 2017\u2013November 2025). Anorectal swabs were tested for\n                      <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                      by NAAT and positive samples were genotyped by PCR-RFLP targeting\n                      <jats:italic toggle=\"yes\">ompA<\/jats:italic>\n                      . Monthly LGV positivity was analyzed using the modified Farrington algorithm to detect epidemic peaks and seasonality, with sensitivity analysis excluding months with &lt;7 samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 700 anorectal swabs, 285 (41%) were\n                      <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                      positive. Among public-hospital samples with conclusive genotyping, 148\/179 (83%) were LGV; in the private center, 78 additional LGV cases were confirmed, totaling 226 LGV cases. HIV coinfection was 78% in LGV versus 100% in non-LGV cases (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0016). Concurrent\n                      <jats:italic toggle=\"yes\">T. pallidum<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">N. gonorrhoeae<\/jats:italic>\n                      infection occurred in 25% of cases and was associated with LGV. The endemic baseline was approximately 32% (range 28\u201336%), with no seasonal pattern or trend. Pandemic-era epidemic alarms disappeared after excluding low-volume months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Anorectal LGV is endemic in Buenos Aires, with no seasonality, and a \u223c32% pre-test probability among symptomatic patients at specialized clinics. This supports considering empirical 3-week doxycycline for MSM with rectal symptoms and\n                      <jats:italic toggle=\"yes\">C. trachomatis<\/jats:italic>\n                      infection when genotyping is unavailable, until further trials confirm the non-inferiority of proposed shortened regimens. Biovar-specific testing remains the goal for targeted therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09564624261486772","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:58:36Z","timestamp":1788901116000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anorectal lymphogranuloma venereum (LGV) circulation dynamics in Buenos Aires: Nine-year surveillance and therapeutic implications"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5898-6667","authenticated-orcid":false,"given":"Laura","family":"Svidler L\u00f3pez","sequence":"first","affiliation":[{"name":"Hospital General de Agudos Juan A. Fern\u00e1ndez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-3002","authenticated-orcid":false,"given":"Lucas Mat\u00edas","family":"Tomatis","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Juan A. Fern\u00e1ndez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2624-7428","authenticated-orcid":false,"given":"Joseph Carlos","family":"Torres Guerrero","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Juan A. Fern\u00e1ndez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-6407","authenticated-orcid":false,"given":"Deysi","family":"L\u00f3pez Aquino","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Juan A. Fern\u00e1ndez"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-7956","authenticated-orcid":false,"given":"Luciana","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Centro Privado de Cirug\u00eda y Coloproctolog\u00eda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Andrea","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luc\u00eda","family":"Gallo Vaulet","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Carolina","family":"Entrocassi","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Rodr\u00edguez Fermepin","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/423966"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15729"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/EID2201.141867"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2503.180600"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5595"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7004a1"},{"key":"e_1_3_2_8_2","volume-title":"Recomendaciones de diagn\u00f3stico y tratamiento de las infecciones de transmisi\u00f3n sexual 2025","author":"Sociedad Argentina de Infectolog\u00eda","year":"2025","unstructured":"Sociedad Argentina de Infectolog\u00eda. Recomendaciones de diagn\u00f3stico y tratamiento de las infecciones de transmisi\u00f3n sexual 2025, 2025. https:\/\/www.sadi.org.ar\/publicaciones\/1871-recomendaciones-de-diagnostico-y-tratamiento-de-las-infecciones-de-transmision-sexual-2025 (Accessed 20 May 2026)."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001963"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000002065"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2025.09.009"},{"key":"e_1_3_2_12_2","unstructured":"UK Health Security Agency. Trends of lymphogranuloma venereum (LGV) in England: 2014 to 2024. https:\/\/www.gov.uk\/government\/publications\/lgv-infections-in-the-uk-trends-and-epidemiology\/trends-of-lymphogranuloma-venereum-lgv-in-england-2014-to-2024 (2025) (Accessed 20 May 2026)."}],"container-title":["International Journal of STD &amp; AIDS"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624261486772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09564624261486772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09564624261486772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:55:02Z","timestamp":1789062902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09564624261486772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":11,"alternative-id":["10.1177\/09564624261486772"],"URL":"https:\/\/doi.org\/10.1177\/09564624261486772","relation":{},"ISSN":["0956-4624","1758-1052"],"issn-type":[{"value":"0956-4624","type":"print"},{"value":"1758-1052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"article-number":"09564624261486772"}}